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Psoriasis and vitamin A

Plasma transport and skin content of retinol, dehydroretinol and carotenoids in adult patients versus healthy controls

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Summary

The vitamin-A status of 107 patient with psoriasis and 37 healthy controls was investigated. The mean serum level of retinol-binding protein (RBP) was normal in the 79 patients with chronic plaque psoriasis covering 25% or less of the skin surface. In the 28 patients with more extensive plaque lesions or pustular/ erythrodermic psoriasis, the mean serum RBP level was significantly lower than in the controls (P<0.05). The cutaneous concentrations of retinol (vitamin A1), dehydroretinol (vitamin A2) and carotenoids were measured in extracts of saponified shave-biopsy specimens of uninvolved and involved skin from 33 patients with plaque psoriasis. Their retinol values did not differ significantly from those found in control skin (mean, 252 ng/g), whereas the carotenoid levels in both uninvolved and involved skin were 25%–50% lower. In contrast, the dehydroretinol concentration was higher in the patients' involved skin (mean, 237 ng/g) than in their uninvolved skin (94 ng/g) and healthy control skin (70 ng/g; P<0.01). Although the origin of increased dehydroretinol levels in involved psoriatic skin is unknown, similar increments were observed in control epidermis in which proliferation had been induced by tape stripping. In 7 patients treated with oral etretinate (aromatic retinoid) for 2–3 weeks, the median retinol and dehydroretinol levels in involved skin increased by 107% and 212%, respectively; the vitamin-A concentrations in uninvolved skin did not change significantly. Oral treatment with β-carotene/canthaxanthin raised the median carotenoid levels in uninvolved and involved skin by 170% and 610%, respectively, without significantly affecting the vitamin-A composition.

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References

  1. Benoldi D, Manfredi G, Pezzarossa E, Allegra F (1981) Retinol binding protein in normal human skin and in cutaneous disorders. Br J Dermatol 105:659–665

    Google Scholar 

  2. Budowski P, Gross J (1965) Conversion of carotenoids to 3-dehydroretinol (vitamin A2) in the mouse. Nature 206:1254–1255

    Google Scholar 

  3. Colton T (1974) Statistics in medicine. Little, Brown and Company, Boston, pp 219–221

    Google Scholar 

  4. Eckert R, Green H (1984) Cloning of cDNAs specifying vitamin-A-responsive human keratins. Proc Natl Acad Sci USA 81:4321–4325

    Google Scholar 

  5. Fritsch PO, Pohlin G, Längle U, Elias P (1981) Response of epidermal cell proliferation to orally administered aromatic retinoid. J Invest Dermatol 77:287–291

    Google Scholar 

  6. Fuchs E, Green H (1981) Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell 25:617–625

    Google Scholar 

  7. Goodwin TW (1980) The biochemistry of the carotenoids, 2nd edn. Chapman and Hall, New York, pp 9–22

    Google Scholar 

  8. Hoffmann R, Schneider A, Quamo Y (1950) The sex difference in vitamin A metabolism. J Invest Dermatol 15:409–419

    Google Scholar 

  9. Klein-Szanto AJP, Martin DH, Pine AH (1980) Cutaneous manifestations in rats with advanced vitamin A deficiency. J Cutan Pathol 7:260–270

    Google Scholar 

  10. Lauharanta J (1981) Vitamin A transport complex during treatment with an oral aromatic retinoid (Ro 10-9359). Acta Derm Venereol (Stockh) 61:264–267

    Google Scholar 

  11. Lee R, Mathews-Roth MM, Pathak MA, Parrish JA (1975) The detection of carotenoid pigments in human skin. J Invest Dermatol 64:175–177

    Google Scholar 

  12. Leitner ZA, Moore T (1946) Vitamin A and skin disease. Lancet 2:262–265

    Google Scholar 

  13. LeVine MJ, McGilvray N, Baden HP (1980) Effect of therapy on keratin polypeptide profiles of psoriatic epidermis. Arch Dermatol 116:1028–1030

    Google Scholar 

  14. Michaëlsson G, Vahlquist A, Juhlin L (1977) Serum zinc and retinol-binding protein in acne. Br J Dermatol 96:283–286

    Google Scholar 

  15. Mier PD, van den Hurk J (1974) Plasma vitamin A levels in the common dermatoses. Br J Dermatol 91:155–159

    Google Scholar 

  16. Moore T (1957) Vitamin A. Elsevier, Amsterdam, pp 586–588

    Google Scholar 

  17. Pinkus H (1951) Examination of the epidermis by the strip method. II. Biometric data on regeneration of the human epidermis. J Invest Dermatol 19:431–446

    Google Scholar 

  18. Rask L, Anundi H, Böhme J, Eriksson U, Ronne H, Sege K, Peterson PA (1981) Structural and functional studies of vitamin A-binding proteins. Ann NY Acad Sci 359:79–90

    Google Scholar 

  19. Rollman O, Vahlquist A (1981) Cutaneous vitamin A levels in seborrheic keratosis, actinic keratosis, and basal cell carcinoma. Arch Dermatol Res 270:193–196

    Google Scholar 

  20. Rollman O, Vahlquist A (1983) Retinoid concentrations in skin, serum and adipose tissue of patients treated with etretinate. Br J Dermatol 109:439–447

    Google Scholar 

  21. Rollman O, Vahlquist A (1985) Vitamin A in skin and serum: Studies of ichthyosis vulgaris, lichen planus, acne and atopic dermatitis Br J Dermatol (in press)

  22. Ray AA (ed) (1982) SAS user's guide: Statistics. SAS Institute, Cary, USA, pp 139–199

    Google Scholar 

  23. Todesco S, Punzi L, Meani A, Gambari PF, Borsatti A (1981) Retinol-binding protein in rheumatoid arthritis. Arthritis Rheum 24:105–106

    Google Scholar 

  24. Törmä H, Vahlquist A (1984) Vitamin A uptake by human skin in vitro. Arch Dermatol Res 276:390–395

    Google Scholar 

  25. Vahlquist A (1980) The identification of dehydroretinol (vitamin A2) in human skin. Experientia 36:317–318

    Google Scholar 

  26. Vahlquist A (1982) Vitamin A in human skin. I. Detection and identification of retinoids in normal epidermis. J Invest Dermatol 79:89–93

    Google Scholar 

  27. Vahlquist A, Rollman O (1984) Further observations on the pharmacology of retinoids. In: Cunliffe WJ, Miller AJ (eds) Retinoid therapy: A review of clinical and laboratory research. MTP Press, Lancaster, pp 135–143

    Google Scholar 

  28. Vahlquist A, Sjölund K, Nordén Å, Peterson PA, Stigmar G, Johansson B (1978) Plasma vitamin A transport and visual dark adaptation in diseases of the intestine and liver. Scand J Clin Lab Invest 38:301–308

    Google Scholar 

  29. Vahlquist A, Michaëlsson G, Juhlin L (1978) Acne treatment with oral zinc and vitamin A: Effects on the serum levels of zinc and retinol binding protein (RBP). Acta Derm Venereol (Stockh) 58:437–442

    Google Scholar 

  30. Vahlquist A, Berne B, Berne C (1982) Skin content and plasma transport of vitamin A and β-carotene in chronic renal failure. Eur J Clin Invest 12:63–67

    Google Scholar 

  31. Vahlquist A, Lee JB, Michaëlsson G, Rollman O (1982) Vitamin A in human skin. II. Concentrations of carotene, retinol and dehydroretinol in various components of normal skin. J Invest Dermatol 79:94–97

    Google Scholar 

  32. Vahlquist A, Lee JB, Michaëlsson G (1982) Darier's disease and vitamin A: Concentrations of retinoids in serum and epidermis of untreated patients. Arch Dermatol 118:389–392

    Google Scholar 

  33. Weinstein G, Frost P (1968) Abnormal cell proliferation in psoriasis. J Invest Dermatol 50:254–259

    Google Scholar 

  34. Weinstein G, McCullough JL, Ross P (1984) Cell proliferation in normal epidermis. J Invest Dermatol 82:623–628

    Google Scholar 

  35. Weiss R, Eichner R, Sun T-T (1984) Monoclonal antibody analysis of keratin expression in epidermal diseases: A 48-and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 98:1397–1406

    Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, University Hospital, S-75185, Uppsala, Sweden

    O. Rollman & A. Vahlquist

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  1. O. Rollman
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  2. A. Vahlquist
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Rollman, O., Vahlquist, A. Psoriasis and vitamin A. Arch Dermatol Res 278, 17–24 (1985). https://doi.org/10.1007/BF00412490

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