Summary
The field studies leading to possible intervention procedures are reviewed. Currently the most promising form of intervention is the prevention of aflatoxin contamination of foodstuffs. It is essential that these are monitored and their efficacy in lowering the incidence of liver cancer measured. The association of liver cancer with hepatitis B infection may be a confounding factor and the impact of this on the study population must also be considered. The imminent production of vaccines for hepatitis B infection may provide an alternative or additional mode of intervention. The possibilities for intervention in liver cell cancer appear one of the brighter prospects for primary prevention of a cancer.
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References
Krishnamachari KAVR, Bhat RV, Nagarajan V, Tilak TBG (1975) Hepatitis due to aflatoxicosis —an outbreak in Western India. Lancet 1:1061–1963
Linsell CA (1979) Decisions on the control of a dietary carcinogen-aflatoxin. In: Davis W, Rosenfeld C (eds) Carcinogenic Risks/Strategies for Intervention. IARC Scientific Publications (Lyon). No 25:111–122
Szmuness W (1979) Large-scale efficacy trials of hepatitis B vaccines in the USA: Baseline data and protocols. J Med Virol 4:327–340
Valenzuela P, Gray, P, Quiroga M, Zaldivar J, Goodman HM, Rutter WJ (1979) Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature, 280:815–819
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Linsell, C.A. Liver cell cancer — Intervention studies. J Cancer Res Clin Oncol 99, 51–56 (1981). https://doi.org/10.1007/BF00412442
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DOI: https://doi.org/10.1007/BF00412442