Advertisement

Increase of whole blood lactic acid concentration during exercise as predicted from pH andPCo2 determinations

  • B. F. Visser
  • Joh. Kreukniet
  • A. H. J. Maas
Article

Abstract

In 67 test subjects, an attempt was made to establish whether it is possible to predict the change in the lactic acid concentration of the arterial blood during excercise from the calculated metabolic change in the bicarbonate concentration of the arterial blood during exercise. The changes in the HCO 3 and the lactic acid concentration averaged —4.15 and 4.41 mEq./l, respectively.

It was found possible to predict the measured change in lactic acid concentration from the change in HCO 3 concentration calculated from the pH and the PCo2. A respiratory correction in the calculation ensured the best correlation coefficient (0.81).

The regression equation was Δlactic acid=0.29−0.99 ΔHCO 3 metabolic.

An equally good approximation was attained in calculating the change of lactic acid concentration from the total change in bicarbonate concentration, with application of a simplified respiratory correction: Δlactic acid=0.33−0.97 (ΔHCO 3 total −0.18 ΔPCo2).

The correlation coefficient remained 0.81.

Keywords

Bicarbonate Lactic Acid Human Physiology Acid Concentration Metabolic Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barker, S. B., and W. H. Summerson: The colorometric determination of lactic acid in biological material. J. biol. Chem. 138, 535 (1941).Google Scholar
  2. Barr, D. P., P. Himmich, E. Harold, and R. P. Green: Studies in the physiology of muscular exercise J. biol. Chem. 55, 495 (1923).Google Scholar
  3. Coster, A. de R. Messin et H. Denolin: Acide lactique, pouls et électrocardiogramme au cours de l'ergospirométrie. Poumon 19, 633 (1963).Google Scholar
  4. Kroon, T. A. J.: Onderzoekingen tijdens het verrichten van arbeid. Thesis Utrecht 1959.Google Scholar
  5. Siggard-Andersen, O., K. Engel, K. Jørgensen, and P. Astrup. A micromethod for determination of pH, carbon dioxide tension, base excess and standard bicarbonate in capillary blood. Scand. J. clin. Lab. Invest. 12, 173 (1960).Google Scholar
  6. Ström G.: The influence of anoxia on lactate utilization in man after prolonged muscular work. Acta physiol. scand. 17, 440 (1959).Google Scholar

Copyright information

© Springer-Verlag 1964

Authors and Affiliations

  • B. F. Visser
    • 1
  • Joh. Kreukniet
    • 1
    • 2
  • A. H. J. Maas
    • 1
  1. 1.From the Department of Pulmonary DiseaseState University HospitalUtrecht
  2. 2.Afdeling LongziektenGeneeskundige Univ.-KliniekUtrechtNiederlande

Personalised recommendations