Increase of whole blood lactic acid concentration during exercise as predicted from pH andPCo2 determinations

  • B. F. Visser
  • Joh. Kreukniet
  • A. H. J. Maas


In 67 test subjects, an attempt was made to establish whether it is possible to predict the change in the lactic acid concentration of the arterial blood during excercise from the calculated metabolic change in the bicarbonate concentration of the arterial blood during exercise. The changes in the HCO 3 and the lactic acid concentration averaged —4.15 and 4.41 mEq./l, respectively.

It was found possible to predict the measured change in lactic acid concentration from the change in HCO 3 concentration calculated from the pH and the PCo2. A respiratory correction in the calculation ensured the best correlation coefficient (0.81).

The regression equation was Δlactic acid=0.29−0.99 ΔHCO 3 metabolic.

An equally good approximation was attained in calculating the change of lactic acid concentration from the total change in bicarbonate concentration, with application of a simplified respiratory correction: Δlactic acid=0.33−0.97 (ΔHCO 3 total −0.18 ΔPCo2).

The correlation coefficient remained 0.81.


Bicarbonate Lactic Acid Human Physiology Acid Concentration Metabolic Change 
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Copyright information

© Springer-Verlag 1964

Authors and Affiliations

  • B. F. Visser
    • 1
  • Joh. Kreukniet
    • 1
    • 2
  • A. H. J. Maas
    • 1
  1. 1.From the Department of Pulmonary DiseaseState University HospitalUtrecht
  2. 2.Afdeling LongziektenGeneeskundige Univ.-KliniekUtrechtNiederlande

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