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Influence of serumalbumin and dextran on sodium and water excretion by the isolated dog kidney

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Summary

The addition of serumalbumin or of dextran reduces sodium and water excretion by isolated kidneys submitted to a saline load. While dextran supplementation produces a considerable drop of glomerular filtration, serumalbumin supplementation induces only slight changes in filtration; a proportional increase of tubular reabsorption is observed. The difference between the response to dextran and serumalbumin may be related to differences in intrarenal blood circulation. Changes in plasma protein concentration play a role in autonomous renal response to saline loading and influence tubular sodium reabsorption. This autonomous renal response is primarily related to plasma dilution.

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  1. Institut de Médecine, Département de Clinique et de Sémiologie médicales, University of Liège, Belgium, Belgium

    A. Nizet

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  1. A. Nizet
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This work has been performed with the help of the “Fonds National de la Recherche Scientifique”.

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Nizet, A. Influence of serumalbumin and dextran on sodium and water excretion by the isolated dog kidney. Pflügers Arch. 301, 7–15 (1968). https://doi.org/10.1007/BF00412414

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  • DOI: https://doi.org/10.1007/BF00412414

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