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The effects of certain psychotropic agents on the conditioned emotional response behavior pattern of the albino rat

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Summary

The conditioned emotional response (CER) testing procedure was utilized as a drug screening test. Two control compounds, chlorpromazine and reserpine, and one experimental compound 5-(O-methoxyphenoxy-methyl)-2-oxazolidinone, were tested in various doses in the CER program. None of the drugs produced an attenuation of the “anxiety” response in the rat. It would appear that the CER program, as presented in this study, is not suitable as a screening procedure for the evaluation of potential ataractic agents.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Pittsburgh, Pittsburgh, Penna, USA

    William J. Kinnard, Mario D. G. Aceto & Joseph P. Buckley

Authors
  1. William J. Kinnard
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  2. Mario D. G. Aceto
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  3. Joseph P. Buckley
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Additional information

This work was supported by research grant MY-3029, National Institutes of Mental Health.

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Kinnard, W.J., Aceto, M.D.G. & Buckley, J.P. The effects of certain psychotropic agents on the conditioned emotional response behavior pattern of the albino rat. Psychopharmacologia 3, 227–230 (1962). https://doi.org/10.1007/BF00412111

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  • DOI: https://doi.org/10.1007/BF00412111

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