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Evaluation of centrally acting drugs in mice with fighting behaviour induced by isolation

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Summary

A modification of a method to evaluate drugs with tranquilizing activity in male mice with fighting behaviour induced by isolation is described. Reduction in fighting time rather than a reduction in the incidence of fighting episodes is used as a criterion of evaluation. The dose response regression lines for chlorpromazine, chlordiazepoxide and meprobamate obtained with this method are given.

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References

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Authors and Affiliations

  1. Department of Pharmacology, Medical Research Laboratories, Chas. Pfizer & Co., Groton, Conn., USA

    A. Scriabine & M. Blake

Authors
  1. A. Scriabine
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  2. M. Blake
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Scriabine, A., Blake, M. Evaluation of centrally acting drugs in mice with fighting behaviour induced by isolation. Psychopharmacologia 3, 224–226 (1962). https://doi.org/10.1007/BF00412110

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  • DOI: https://doi.org/10.1007/BF00412110

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