Skip to main content
SpringerLink
Log in

Comparison of psilocin with psilocybin, mescaline and LSD-25

  • Short Communications
  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Summary

  1. 1.

    Reactions induced by LSD, mescaline, psilocin, and psilocybin are qualitatively similar.

  2. 2.

    The time course of the psilocin and psilocybin reactions are shorter than those of LSD or mescaline reactions. li

  3. 4.

    Psilocin is approximately 1.4 times as potent as psilocybin. This ratio is the same as that of the molecular weights of the two drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Abramson, H. A., M. E. Jarvik, M. R. Kaufman, C. Kornetsky, A. Levine and M. Wagner: Lysergic acid diethylamide (LSD-25): I. Physiological and perceptual responses. J. Psychol. (Provincetown) 39, 3–60 (1955).

    Google Scholar 

  • Gaddum, J. H.: Bioassays and mathematics. Pharmacol. Rev. 5, 87–134 (1953).

    Google Scholar 

  • Hofmann, A., A. Frey, H. Ott, Th. Petrzilka u. F. Troxler: Konstitutionsaufklärung und Synthese von Psilocybin. Experientia (Basel) 14, 397–399 (1958).

    Google Scholar 

  • , u. F. Troxler: Identifizierung von Psilocin. Experientia (Basel) 15, 101–102 (1959).

    Google Scholar 

  • Horita, A., and L. J. Weber: The enzymic dephosphorylation and oxidation of psilocybin and psilocin by mammalian tissue homogenates. Biochem. Pharmacol. 7, 47–54 (1961).

    Google Scholar 

  • Isbell, H.: Comparison of the reactions induced by psilocybin and LSD-25 in man. Psychopharmacologia 1, 29–38 (1959).

    Google Scholar 

  • , R. E. Belleville, H. F. Fraser, A. Wikler and C. R. Logan: Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication. A.M.A. Arch. Neurol. Psychiat. 76, 468–478 (1956).

    Google Scholar 

  • Wolbach, A. B., H. Isbell and E. J. Miner: Cross tolerance between mescaline and LSD-25. With a comparison of the mescaline and LSD-reactions. (In press.)

Download references

Author information

Authors and Affiliations

  1. National Institute of Mental Health, Addiction Research Center, Public Health Service Hospital, Lexington, Kentucky, USA

    A. B. Wolbach Jr., E. J. Miner & Harris Isbell

Authors
  1. A. B. Wolbach Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. J. Miner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Harris Isbell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wolbach, A.B., Miner, E.J. & Isbell, H. Comparison of psilocin with psilocybin, mescaline and LSD-25. Psychopharmacologia 3, 219–223 (1962). https://doi.org/10.1007/BF00412109

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00412109

Keywords

Search

Navigation