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The inactivation of 5-hydroxytryptamine by blood platelets in mental deficiency with elevated serum 5-hydroxytryptamine

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Summary

The mentally defective patients were divided into two groups according to the 5-hydroxytryptamine (5HT) content in serum. In the first (“normal”) group were those with values <200 ng/ml (6 mongolisms, 4 cerebral palsies) and in the second those with values >200 ng/ml (7 cerebral palsies, 5 encephalopathies).

The content of 5HT per platelet was twice as high in the second than in the first group. When the platelet-rich plasma was incubated with tetrabenazine in vitro equal amounts of 5HT were liberated from platelets in both groups. During the liberation slightly more of the 5 HT (in percent from released) was inactivated in the first group than in the second. The ability of platelets to inactivate 5 HT under these experimental conditions does not explain the higher serum and platelet values found in some patients.

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Authors and Affiliations

  1. Department of Pharmacology, University of Helsinki, Finland

    M. K. Paasonen & E. Kivalo

  2. Research Department of Rinnekoti Institute of Mental Deficiency, Helsinki, Finland

    M. K. Paasonen & E. Kivalo

Authors
  1. M. K. Paasonen
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  2. E. Kivalo
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Paasonen, M.K., Kivalo, E. The inactivation of 5-hydroxytryptamine by blood platelets in mental deficiency with elevated serum 5-hydroxytryptamine. Psychopharmacologia 3, 188–192 (1962). https://doi.org/10.1007/BF00412104

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  • DOI: https://doi.org/10.1007/BF00412104

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