Skip to main content
SpringerLink
Log in

Interaction of the effects of tyramine, amphetamine and reserpine in man

  • Original Investigations
  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Summary

  1. 1.

    The pressor response to tyramine has been investigated in untreated subjects and again after treatment with reserpine. Reserpine was found to produce a significant reduction in the pressor effect of tyramine.

  2. 2.

    Amphetamine continues to produce euphoria and alerting after treatment with reserpine, but its effects are reduced by large doses of chlorpromazine.

  3. 3.

    The symptoms produced by large doses of reserpine are rapidly abolished by an intravenous injection of amphetamine.

  4. 4.

    These findings are discussed in relation to current theories of action of amphetamine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bartlett, J. E. A.: Place of methyl phenidate hydrochloride in psychiatric practice. Brit. med. J. 1959I, 48.

  • Brodie, B. B., A. Pletscher and P. A. Shore: Evidence that serotonin has a role in brain function. Science 122, 968 (1955).

    Google Scholar 

  • Burn, J. H.: Tyramine and other amines as noradrenaline releasing substances. Adrenergic Mechanisms, ed. J. R. Vane, G. E. W. Wolstenholme, M. O'Connor, p. 326. London: Churchill 1960.

    Google Scholar 

  • Burton, R. M., M. A. Sodd and A. Goldin: The analeptic action of lysergic acid diethylamine and d-amphetamine on reserpine-sedated mice. Arch. int. Pharmacodyn. 112, 188 (1957).

    Google Scholar 

  • Carlsson, A.: Brain mono-amines and psychotropic drugs. Neuropsychopharmacology, ed. E. Rothlin, p. 417. Amsterdam: Elsevier 1961.

    Google Scholar 

  • Cole, J., and P. Glees: Ritalin as an antagonist to reserpine in monkeys. Lancet 1956 I, 338.

  • — —: Reserpine and its antagonists methylphenidate (ritalin) and amphetamine in monkeys. Congr. Report of the IInd Internat. Congr. for Psychiatry, Zurich, Switzerland, Sept. 1957, 2, 398 (1957).

    Google Scholar 

  • — —: The effect of methylphenidate and bemigride on monkeys under reserpine or pentobarbitone. Neuropsychopharmacology, ed. P. B. Bradley, P. Dentker and C. Radouco-Thomas, p. 298. Amsterdam: Elsevier 1959.

    Google Scholar 

  • Ehrlich, V., K. Fronkova and L. Slege.: The effect of long term oral combination of methylphenidate and reserpine on the autonomic phenomena at rest and on inborn and acquired reflexes in the dog. Psychopharmacologia (Berl.) 1, 357 (1960).

    Google Scholar 

  • Ferguson, J. T.: Treatment of reserpine-produced depression with a new analeptic: phenidylate. Ann. N. Y. Acad. Sci. 61, 101 (1955).

    Google Scholar 

  • —, and W. H. Funderburk: Improving senile behaviour with reserpine and ritalin. J. Amer. med. Ass. 160, 259 (1956).

    Google Scholar 

  • Greig, M. E., R. A. Walk and A. J. Gibbons: The effect of three tryptamine derivatives on serotonin metabolism in vitro and in vivo. J. Pharmacol. exp. Ther. 127, 110 (1959).

    Google Scholar 

  • Ivy, A. C., and L. R. Krashno: Amphetamine (benzedrine) sulphate: a review of its pharmacology. War Med. (Chic.) 1, 15 (1941).

    Google Scholar 

  • Marshall, E. F., G. S. Stirling, A. C. Tait and A. Todrick: The effect of iproniazid and imipramine on the platelet 5-hydroxy-tryptamine level in man. Brit. J. Pharmacol. 15, 35 (1960).

    Google Scholar 

  • Meyer, F., u. H. Eckers: Kreislaufwirkung des Tyramin (nach Untersuchungen am Menschen). Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 189, 200 (1938).

    Google Scholar 

  • Plummer, A. J., R. A. Maxwell and A. E. Earl: The influence of ritalin (methylphenidate) on the behavioural and circulatory effects of reserpine. Schweiz. med. Wschr. 87, 370 (1957).

    Google Scholar 

  • Reinert, H.: The effects of amphetamine on peripheral synaptic structures. Neuropsychopharmacology, ed. P. B. Bradley, P. Deniker and C. Radouco-Thomas, p. 399. Amsterdam: Elsevier 1959.

    Google Scholar 

  • Vane, J. R.: The action of sympathomimetic amines on tryptamine receptors. “Adrenergic mechanisms”, ed. J. R. Vane, G. E. W. Wolstenholme and M. O'Connor, p. 356. London: Churchill 1960a.

    Google Scholar 

  • —: In: Adrenergic mechanisms, ed. J. R. Vane, G. E. W. Wolstenholme and M. O'Connor, p. 523. London: Churchill 1960b.

    Google Scholar 

  • —, H. O. J. Collier, S. J. Corne, E. Marley and P. B. Bradley: Tryptamine receptors in the central nervous system. Nature (Lond.) 191, 1068, (1961).

    Google Scholar 

  • Wodraska, T. M., J. C. Saunders and N. S. Kline: Combined ritalin and serpasil therapy in chronic psychoses. Dis. nerv. Syst. 19, 122 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Maudsley Hospital, London

    M. G. Gelder & J. R. Vane

  2. Department of Pharmacology Institute of Basic Medical Sciences, Royal College of Surgeons of England, England

    M. G. Gelder & J. R. Vane

Authors
  1. M. G. Gelder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. R. Vane
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gelder, M.G., Vane, J.R. Interaction of the effects of tyramine, amphetamine and reserpine in man. Psychopharmacologia 3, 231–241 (1962). https://doi.org/10.1007/BF00411364

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00411364

Keywords

Search

Navigation