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Comportement de la radioactivité hématique après administration de la 5-hydroxytryptamine-C14 chez des sujets normaux et schizophrènes

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Summary

The blood radioactivity curve after i.v. injection of 1 microC/kg of C14 labeled serotonin runs significantly lower in schizophrenic than in normal subjects.

This finding suggests that the enzymatic degradation of exogenous serotonin might be quicker or its binding be easier by the tissues in schizophrenic patients.

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Bibliographie

  • Axelrod, J., and J. K. Inscoe: The uptake and binding of circulating serotonin and the effect of drugs. J. Pharmacol. exp. Ther. 141, 161–164 (1963).

    Google Scholar 

  • Banerjee, S., and P. S. Agarwal: Tryptophan-nicotinic acid metabolism in schizophrenia. Proc. Soc. exp. Biol. (N. Y.) 97, 657–659 (1958).

    Google Scholar 

  • Bozzi, R., A. Allegranza e A. Bruno: Effetti del trattamento con reserpina, cloropromazina, haloperidol, elettroshock sulla eliminazione urinaria dell'acido 5-IIA in schizofrenici. Correlazioni clinico-biologiche. Riv. Pat. nerv. ment. 84, 49–65 (1963).

    Google Scholar 

  • Buscaino, G. A., e L. Stefanachi: Contributo al metabolismo delle sostanze indoliche, con particolare riguardo all'acido 5-idrossindolacetico nella schizofrenia. Confin. neurol. (Basel) 18, 188–195 (1958).

    Google Scholar 

  • Feldstein, A., H. Hoagland, and H. Freeman: Blood and urinary serotonin and 5-hydroxyindolacetic acid levels in schizophrenic patients and normal subjects. J. nerv. ment. Dis. 129, 62–68 (1959).

    Google Scholar 

  • Forrest, A. D.: Indoluria in schizophrenia: I. Statistical study and investigation of hepatic function. J. ment. Sci. 105, 674–692 (1959).

    Google Scholar 

  • Kopin, I. J.: Tryptophan loading and excretion of 5-hydroxyindolacetic acid in normal and schizophrenic subjects. Science 129, 835–836 (1959).

    Google Scholar 

  • Leyton, G. B.: Indolic compounds in the urine of schizophrenics. Brit. med. J. 1958 II, 1136–1139.

    Google Scholar 

  • McGeer, E. G., W. T. Brown, and P. L. McGeer: Aromatic metabolism in schizophrenia. II. Bidimensional urinary chromatograms. J. nerv. ment. Dis. 125, 176–180 (1957).

    Google Scholar 

  • McGeer, P. L., E. G. McGeer, A. Feldstein, H. Hoagland, M. R. Riviera, and H. Freeman: Metabolism of radioactive serotonin in psychotics treated with Mao inhibitor. J. Neuropsychiat. 1, 274–275 (1960).

    Google Scholar 

  • Rodnight, R., and E. K. Aves: Body fluid indoles of normal and mentally-ill subjects. J. ment. Sci. 104, 1149–1159 (1958).

    Google Scholar 

  • Sano, I.: Die Bedeutung der Indolderivate in der Pathogenese-Forschung der endogenen Psychosen. Confin. neurol. (Basel) 18, 196–204 (1958).

    Google Scholar 

  • Sprince, H., E. Houser, D. Jameson, and C. Dohan: Differential extraction of indoles from the urine of schizophrenic and normal subjects. Arch. gen. Psychiat. 2, 268–270 (1960).

    Google Scholar 

  • Wolley, D. W., and E. Shaw: A biochemical suggestion about certain mental disorders. Proc. nat. Acad. Sci. (Wash.) 40, 228–231 (1954).

    Google Scholar 

  • Zeller, E. A.: The role of amine oxidase in the destruction of catecholamines. Pharmacol. Rev. 11, 387–393 (1959).

    Google Scholar 

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Authors and Affiliations

  1. Istituto Ospedaliero Provinciale ≪Paolo Pini≫, Milano

    D. de Maio, G. Pasquariello, A. Bruno & L. Faggioli

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  1. D. de Maio
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  2. G. Pasquariello
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  3. A. Bruno
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  4. L. Faggioli
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de Maio, D., Pasquariello, G., Bruno, A. et al. Comportement de la radioactivité hématique après administration de la 5-hydroxytryptamine-C14 chez des sujets normaux et schizophrènes. Psychopharmacologia 7, 230–234 (1965). https://doi.org/10.1007/BF00411220

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  • DOI: https://doi.org/10.1007/BF00411220

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