Effects of Cannabis sativa (marihuana) on maze performance of the rat

Summary

Male Wistar rats injected with a Cannabis sativa (marihuana) extract 3 minutes before or 30 seconds after trials, were compared to a control group for performance in a Lashley III alley maze. Animals that had received cannabis 3 minutes before trials were better performers than controls; on the other hand, posttrial injections were found to increase the running time of the subjects, although the number of errors remained the same as in the control rats. Five out of 32 rats receiving cannabis were disrupted by the treatment. These findings are discussed in the light of the perseveration-consolidation theory of memory.

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References

  1. Adams, R., and B. R. Baker: Structure of Cannabidiol. VI. A method of synthesis of a tetrahydrocannabinol which possesses marihuana activity. J. Amer. chem. Soc. 62, 2405–2408 (1940).

    Google Scholar 

  2. —: M. Harfenist, and S. Loewe: New analogs of tetrahydrocannabinol. J. Amer. chem. Soc. 71, 1624–1628 (1949).

    Google Scholar 

  3. Allentuck, S.: The Marihuana problem in the city of New York, by the Mayor's Committee on Marihuana, p. 35. Lancaster, Pennsylvania: The Jaques Cattell Press 1944.

    Google Scholar 

  4. Alles, G. A., A. J. Haagen-Smith, G. A. Feigen, and W. B. Dandliker: Evidence of another physiologically active principle in Cannabis sativa (marihuana). J. Pharmacol. exp. Ther. 76, 21–26 (1942).

    Google Scholar 

  5. Anslinger, H. J.: More on marihuana and Mayor La Guardia's committee report. J. Amer. med. Ass. 128, 1187 (1945).

    Google Scholar 

  6. Breen, R. A., and J. L. McGaugh: Facilitation of maze learning with posttrial injections of picrotoxin. J. comp. physiol. Psychol. 54, 498–501 (1961).

    Google Scholar 

  7. Carlini, G. R. S., and E. A. Carlini: Effects of strychnine and Cannabis sativa (marihuana) on the nucleic acid content in brain of the rat. Med. exp. (Basel) (in press).

  8. Chamberlain, T. J., G. H. Rothschild, and R. W. Gerard: Drugs affecting RNA and learning. Proc. nat. Acad. Sci. (Wash.) 49, 918–924 (1963).

    Google Scholar 

  9. Cook, L., A. B. Davidson, D. J. Davis, H. Green, and E. J. Fellows: Ribonucleic acid: Effect on conditioned behavior in rats. Science 141, 268–269 (1963).

    Google Scholar 

  10. Dagirmanjian, R., and E. S. Boyd: Some pharmacological effects of two tetrahydrocannabinols. J. Pharmacol. exp. Ther. 135, 25–33 (1962).

    Google Scholar 

  11. Davis, T. W. M., C. G. Farmilo, and M. Osadchuk: Identification and origin determinations of Cannabis by gas and paper chromatography. Analyt. Chem. 35, 751–754 (1963).

    Google Scholar 

  12. Gaddum, J. H.: Pharmacology. Oxford University Press. London, p. 143 (1953).

    Google Scholar 

  13. Gayer, H.: Pharmakologische Wertbestimmung von orientalischem Haschisch und Herba Cannabis indica. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 129, 312–318 (1928).

    Google Scholar 

  14. Geiling, E. M. K.: Marihuana: America's new drug problem. Ed. R. P. Walton. Philadelphia, Pa.: J. B. Lippincott 1938.

    Google Scholar 

  15. Hebb, D. O.: The organization of behavior. New York: John Wiley and Sons 1949.

    Google Scholar 

  16. Hydén, H., and E. Egyházi: Nuclear RNA changes of nerve cells during a learning experiment in rats. Proc. nat. Acad. Sci. (Wash.) 48, 1366–1373 (1962).

    Google Scholar 

  17. Imbesi, A.: Sull'attivita farmacologica della canape indiana. Arch. ital. Sci. farmacol. 9, 3–4 (1959).

    Google Scholar 

  18. Lerner, M.: Marihuana: tetrahydrocannabinol and related compounds. Science 140, 175–176 (1963).

    Google Scholar 

  19. Lucena J.: A Maconha, p. 116. Rio de Janeiro: Ministério da Educação do Brasil. 1951.

    Google Scholar 

  20. McGaugh, J. L.: Facilitative and disruptive effects of strychnine sulphate on maze learning. Psychol. Rep. 8, 99–104 (1961).

    Google Scholar 

  21. —, and C. W. Thomson: Facilitation of simultaneous discrimination learning with strychnine sulphate. Psychopharmacologia (Berl.) 3, 166–172 (1962).

    Google Scholar 

  22. — —, W. H. Westbrook and W. J. Hudspeth: A further study of learning facilitation with strychnine sulphate. Psychopharmacologia (Berl.) 3, 352–360 (1962).

    Google Scholar 

  23. —, W. H. Westbrook, and C. W. Thomson: Facilitation of maze learning with posttrial injections of 5,7-diphenyl-1,3-diazadamantan-6-ol (1757 I. S.). J. comp. physiol. Psychol. 55, 710–713 (1962a).

    Google Scholar 

  24. Veiga, E. P., and A. R. Pinho: Contribuição ao estudo do cannabismo no Brasil. Neurobiologia 25, 38–68 (1962).

    Google Scholar 

  25. Wollner, H. T., J. R. Matchett, J. Levine, and S. Loewe: Isolation of a physiologically active tetrahydrocannabinol from Cannabis sativa resin. J. Amer. chem. Soc. 64, 26–29 (1942).

    Google Scholar 

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Carlim, E.A., Kramer, C. Effects of Cannabis sativa (marihuana) on maze performance of the rat. Psychopharmacologia 7, 175–181 (1965). https://doi.org/10.1007/BF00411216

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Keywords

  • Posttrial Injection
  • Good Performer
  • Maze Performance
  • Cannabis Sativa
  • Alley Maze