Summary
Monoamine oxidase inhibitors suppressed REM sleep during longitudinal sleep studies in four subjects. While the REM suppression occurred during maximum dosages, one normal subject showed an increase in REM time during the initial phase of drug administration. One patient had a marked REM compensation after the drug was discontinued. There were no consistent changes in Non-REM sleep. Monoamine oxidase inhibition was measured by plasma and platelet studies, as well as by 24-hour urinary tryptamine levels.
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We wish to thank Dr. William Bunney and Dr. David Anderson for their assistance
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Wyatt, R.J., Kupfer, D.J., Scott, J. et al. Longitudinal studies of the effect of monoamine oxidase inhibitors on sleep in man. Psychopharmacologia 15, 236–244 (1969). https://doi.org/10.1007/BF00411173
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DOI: https://doi.org/10.1007/BF00411173