Summary
Stimulation of the lateral hypothalamns produced consistently high rates of self-stimulation in cats. Stimulation of the caudate nucleus and anterior commissure also produced reward-effects.
Amphetamine and imipramine increased rates of self-stimulation in cats with electrodes in the lateral hypothalamus, whereas chlorpromazine attenuated self-stimulation. Amphetamine and chlorpromazine, but not imipramine, similarly affected the responding of animals working for stimulation of the caudate nucleus.
A new response-device that appears to have certain advantages over a lever was also described.
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Horovitz, Z.P., Chow, MI. & Carlton, P.L. Self-stimulation of the brain by cats: Technique and preliminary drug-effects. Psychopharmacologia 3, 449–454 (1962). https://doi.org/10.1007/BF00411162
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DOI: https://doi.org/10.1007/BF00411162