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Focal convulsions during barbiturate abstinence in dogs with cerebrocortical lesions

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Summary

In contrast to cerebrocortical lesions induced by a freezing technique, those due to multiple injections of aluminium hydroxide were associated with both focal and generalized convulsions in miniature dogs following abrupt withdrawal of increasing doses of barbital sodium. These withdrawal phenomena appeared after final dose levels of barbiturate comparable to those associated with generalized abstinence convulsions in normal dogs.

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Authors and Affiliations

  1. National Institute of Mental Health, Addiction Research Center, PHS Hospital, Lexington, Kentucky, USA

    Carl F. Essig

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  1. Carl F. Essig
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Essig, C.F. Focal convulsions during barbiturate abstinence in dogs with cerebrocortical lesions. Psychopharmacologia 3, 432–437 (1962). https://doi.org/10.1007/BF00411160

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  • DOI: https://doi.org/10.1007/BF00411160

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