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Qualitative and quantitative relationships between the effects of imipramine and Chlorpromazine on amphetamine group toxicity

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Summary

  1. 1.

    Imipramine in small doses (0.5–1 mg/kg) intensified, but in large doses (60–100 mg,) reduced the toxic effects of amphetamine: motor excitation, agressivity, fighting and lethality in grouped albino mice.

    The different influence of low and high doses of imipramine on the central effects of amphetamine suggests, that dual (positive and negative) action of imipramine on adrenergic synapses, previously observed on peripheral synapses, occurs also in the brain.

  2. 2.

    Chlorpromazine, like imipramine, not only decreased (in doses of 2.5 and 5.0 mg/kg), but also increased (in doses of 0.005–0.01 mg/kg) amphetamine group toxicity. The latter effect may be termed, “paradoxical”.

  3. 3.

    The similarity of both the tranquilizing and analeptic effects of imipramine and chlorpromazine suggests that the mediator natur and possibly the localization of action of two drugs are common.

  4. 4.

    Amphetamine group toxicity may be applied as a sensitive test for evaluation of stimulant (psychoanaleptic) activity.

  5. 5.

    A scheme of qualitative and quantitative relationships between the effects of imipramine and chlorpromazine over wide dose ranges is suggested.

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Authors and Affiliations

  1. Laboratory of Psychopharmacology, Bechterev Psychoneurological Institute, Leningrad, USSR

    I. P. Lapin

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Reported at the Symposium on the Research of Influence of Psychotropic Drugs on Higher Nervous Activity, Prague, October 31st–November 3rd 1961.

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Lapin, I.P. Qualitative and quantitative relationships between the effects of imipramine and Chlorpromazine on amphetamine group toxicity. Psychopharmacologia 3, 413–422 (1962). https://doi.org/10.1007/BF00411158

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  • DOI: https://doi.org/10.1007/BF00411158

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