Skip to main content
Log in

Occluding junctions surrounding cystoid spaces in the human peripheral retina

A thin-section and freeze-fracture study

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

Transmission electron microscopic examination of thin sections and freeze-fracture replicas of areas neighboring cystoid spaces in the peripheral human retina reveals extensive networks of occluding junctions on all sides of these spaces. These junctions may be responsible for the fact that, in spite of the absence of an epithelial lining, fluid from the spaces of cystoid degeneration and retinoschisis does not leak into the surrounding retina, which would lead to their collapse.

Zusammenfassung

Transmissionselektronenmikroskopische Untersuchungen an Dünnschnitten und Gefrierätzungsabdrücken von Regionen in der Nachbarschaft zystoider Hohlräume in der peripheren menschlichen Netzhaut zeigen ein ausgedehntes Netzwerk okkludierender Interzellularverbindungen auf allen Seiten der Hohlräume. Diese Interzellularverbindungen könnten für die Tatsache verantwortlich sein, daß trotz des Fehlens einer epithelialen Auskleidung Flüssigkeit aus den Hohlräumen von zystoiden Degenerationen und Retinoschisisblasen nicht in die umgebende Netzhaut abströmt, was zu einem Kollaps der Hohlräume führen würde.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Blessig R (1855) De retinae textura disquisitiones microscopicae, Inaugural Dissertation, Dorpat

  • Cibis PA (1965) Retinoschisis. Retinal Cysts. Trans Am Ophthalmol Soc 63:417–453

    Google Scholar 

  • Gärtner J (1966) Die Feinstruktur der Netzhaut des menschlichen Auges im Gebiet seniler peripher cystoider Degeneration. Albrecht von Graefes Archiv Klin Ophthalmol 169: 38–61

    Google Scholar 

  • Gärtner J (1973) Extracellular fibril formation by neuroglial cells in cystoid degenerations of the peripheral retina of the human eye. Acta Neuropathol (Berl) 26: 45–57

    Google Scholar 

  • Gärtner J (1974) Periphere cystoide Degenerationen der menschlichen Netzhaut. Eine elektronenmikroskopische Untersuchung. In: Normale und pathologische Anatomie (Eds W Bargmann, W Doerr) Vol 29. Georg Thieme, Stuttgart

    Google Scholar 

  • Gärtner J (1975) Fine structural changes of peripheral cystoid degenerations during life. In: New Research on the Aetiology and Surgery of Retinal Detachment, Modern Problems in Ophthalmology (Ed EB Streiff) Vol 15, pp 98–102. S Karger, Basel

    Google Scholar 

  • Göttinger W (1978) Senile Retinoschisis: Morphological Relationship of the Formation of Spaces Within the Peripheral Retina to Senile Retinoschisis and to Schisis Detachment. Georg Thieme, Stuttgart

    Google Scholar 

  • Harris GS (1968) Retinoschisis: pathogenesis and treatment. Canad J Ophthalmol 3:312–317

    Google Scholar 

  • Inomata H (1966) Electron microscopic observations on cystoid degeneration in the peripheral retina. Invest Ophthalmol 12:354–365

    Google Scholar 

  • Iwanoff A (1869) Beiträge zur normalen und pathologischen Anatomie des Auges. III. Das Oedem der Netzhaut. Albrecht v Grafes Arch Ophthal 15, 88

    Google Scholar 

  • Karnovsky MJ (1967) The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J Cell Biol 35:213–236

    Google Scholar 

  • Luciano L, Thiele J, Reale E (1979) Development of follicles and of occluding junctions between the follicular cells of the thyroid gland. A thin-section and freeze-fracture study in the fetal rat. J Ultrastruct Res 66:164–181

    Google Scholar 

  • Montesano R, Friend DS, Perrelet A, Orci L (1975) In vivo assembly of tight junctions in fetal rat liver. J Cell Biol 67:310–319

    Google Scholar 

  • Moor H, Mühlethaler K (1963) Fine structure in frozen-etched yeast cells. J Cell Biol 17:609–628

    Google Scholar 

  • Reale E, Luciano L, Spitznas M (1974) Introduction to freeze-fracture method in retinal research. Albrecht von Graefes Archiv Klin Ophthalmol 192:73–87

    Google Scholar 

  • Spitznas M (1970) Zur Feinstruktur der sog. Membrana limitans externa der menschlichen Retina. Albrecht von Graefes Archiv Klin Ophthalmol 180:44–56

    Google Scholar 

  • Straatsma BR, Foos RY (1973) Typical and reticular degenerative retinoschisis. Am J Ophthalmol 75:551–575

    Google Scholar 

  • Yanoff BR, Fine BS (1975) Ocular Pathology: A Text and Atlas. Harper & Row, Hagerstown, Maryland

    Google Scholar 

  • Zimmerman LE, Spencer WH (1960) The pathologic anatomy of retinoschisis. Arch Ophthalmol 63:10–20

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This investigation was supported in part by the Wasserman Professorship fund

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spitznas, M., Luciano, L. & Reale, E. Occluding junctions surrounding cystoid spaces in the human peripheral retina. Albrecht von Graefes Arch. Klin. Ophthalmol. 217, 155–165 (1981). https://doi.org/10.1007/BF00411146

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00411146

Keywords

Navigation