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Cannabis metabolites in urine after oral administration

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Summary

Cannabis was administered to volunteers in a dose of 750 mg which was drunk of a “tea”.

Cannabis metabolites were demonstrated in human urine by thin layer chromatography.

The demonstration of urinary metabolites after oral administration was dependent on treatment of the urine with β-glucuronidase. No metabolites were demonstrable in urine not treated by enzyme splitting.

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References

  • Christiansen, J., L. F. Gram, B. Kofod, and O. J. Rafaelsen: Imipramine metabolism in man. A study of urinary metabolites after administration of radioactive imipramine. Psychopharmacologia (Berl.) 11, 255–264 (1967).

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Authors and Affiliations

  1. Psychochemistry Laboratory, Department of Psychiatry and Department of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark

    J. Christiansen & Ole J. Rafaelsen

Authors
  1. J. Christiansen
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  2. Ole J. Rafaelsen
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Christiansen, J., Rafaelsen, O.J. Cannabis metabolites in urine after oral administration. Psychopharmacologia 15, 60–63 (1969). https://doi.org/10.1007/BF00410801

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  • DOI: https://doi.org/10.1007/BF00410801

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