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Histokompatibilitäts (HL-A)-Antigene beim Retinoblastom

HL-A antigens in retinoblastoma

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

Twenty-one HL-A-Antigens of the first and second HL-A series were studied in a total of 122 German children with retinoblastoma and in 64 families. Antigen W5 was found significantly more frequently (p<0.001) and HL-A 12 significantly more rarely (p<0.001) in the patients than in healthy controls. The presence of W5 and the absence of HL-A 12 may be among the factors that influence the penetrance of the retinoblastoma allele or may combine with several other unknown factors to produce an increased susceptibility to the disease.

Zusammenfassung

21 HL-A-Antigene der ersten und zweiten HL-A-Serie wurden bei insgesamt 122 deutschen Kindern mit Retinoblastom und 64 Familien untersucht. Die Frequenz des Antigens W5 war signifikant erhöht (p<0,001), HL-A12 wurde signifikant seltener als bei gesunden Kontrollpersonen gefunden. Das Antigen W5 oder auch das Fehlen von HL-A12 könnten Teilfaktoren sein, die Einfluß auf die Penetranz des erblichen Retinoblastoms haben, oder durch komplexe Kopplung mit unbekannten genetischen Faktoren die Empfänglichkeit für das Retinoblastom bewirken.

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Authors and Affiliations

  1. Klinikum der Gesamthochschule Essen, Universitäts-Augenklinik und Lehrstuhl und Abteilung für Medizinische Virologie und Immunologie, Bundesrepublik Deutschland

    Peter Schildberg, Jörg Bertrams, Wolfgang Hopping & Ernst Kuwert

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  1. Peter Schildberg
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  2. Jörg Bertrams
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  3. Wolfgang Hopping
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  4. Ernst Kuwert
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Additional information

Herrn Prof. Dr. med. W. Müller zum 65. Geburtstag gewidmet.

Die nachfolgenden Untersuchungen wurden durchgeführt mit finanzieller Unterstützung durch das Landesamt für Forschung beim Minister für Wissenschaft und Forschung des Landes Nordrhein-Westfalen.

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Schildberg, P., Bertrams, J., Hopping, W. et al. Histokompatibilitäts (HL-A)-Antigene beim Retinoblastom. Albrecht von Graefes Arch. Klin. Ophthalmol. 186, 33–38 (1973). https://doi.org/10.1007/BF00410076

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  • DOI: https://doi.org/10.1007/BF00410076

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