Summary
A double-blind short-term trial was done to test the effect of guanethidine 3% — adrenaline 0.5% (G-A) in a combined eye drop in 18 patients with open-angle glaucoma and one patient with narrow-angle glaucoma. In 9 of the 19 patients we expected an IOP lowering agent. There was one false-negative result. The mean fall in IOP due to G-A was 10.1 mm Hg (range 3 to 23) and 8.7 mm Hg (range −1 to 26) 6 and 8 h after application respectively. There was no effect on IOP in the 9 eyes that received the placebo.
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Hoyng, P.F.J., Dake, C.L. & Greve, E.L. A double-blind short-term trial of guanethidine 3 % and adrenaline 0.5 % combined in one eye drop. Albrecht von Graefes Arch. Klin. Ophthalmol. 203, 73–80 (1977). https://doi.org/10.1007/BF00410049
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DOI: https://doi.org/10.1007/BF00410049