Summary
We compared combined intravitreal and systemic oxacillin to combined subconjunctival and systemic oxacillin in the treatment of experimental staphylococcal endophthalmitis. Intravitreal injection of 500 mcg was nontoxic to all intraocular structures and produced concentrations in the vitreous bactericidal to all susceptible strains of Staphylococcus aureus for almost 24 hours. In eyes treated 8, 10, and 12 hours after intravitreal inoculation of 10000 to 20000 penicillinase-producing S. aureus organisms, intravitreal injection of 500 mcg of oxacillin was superior to subconjunctival injection of 100 mg when each was combined with seven days of intensive intramuscular oxacillin.
Zusammenfassung
Zur Behandlung einer experimentellen Staphylokokken-Endophthalmitis wurde eine Kombination von intravitrealem und intramuskulärem Oxacillin mit einer Behandlung, bei der subkonjunctivale mit intramuskulären Injektionen von Oxacillin kombiniert wurden, verglichen. Die Injektion von 500 μg in den Glaskörper verursachte keinen intraokulären Schaden und erzeugte eine Glaskörperkonzentration, die für fast 24 Std die empfindlichen Kolonien des Staphylococcus aureus töten konnte. Penicillinase produzierender Staphylococcus aureus (10000–20000 Organismen) wurde in den Glaskörper injiziert. Die Augen wurden dann nach 8,10 und 12 Std behandelt. Eine Injektion von 500 μg Oxacillin in den Glaskörper war erfolgreicher als eine Injektion von 100 mg unter die Bindehaut, wenn beide Methoden mit einer 7 Tage währenden intramuskulären Oxacillin-Therapie verbunden waren.
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This study was supported in part by Public Health Service grant 1107-03 and Illinois Lions Club.
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Kasbeer, R.T., Peyman, G.A. Intravitreal oxacillin in experimental staphylococcal endophthalmitis. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 279–287 (1975). https://doi.org/10.1007/BF00410039
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DOI: https://doi.org/10.1007/BF00410039