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Provoked iris ischaemia in the rabbit

I. Clinical and histopathological examinations

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Summary

Various surgical procedures were performed on albino rabbits, which impaired anterior segment blood circulation. Our early and late clinical observations showed a consequent development of anterior-segment ischaemia into anterior-segment necrosis. The significance of different surgical procedures for resulting complications is discussed. Histopathological observations showed ischaemic changes in the anterior segment: iris and ciliary body atrophy, cataract formation, rubeosis iridis. Even though changes in the anterior segment were not observed on biomicroscopic examination in the cases with ligation of one LPCA, histological studies revealed different degrees of sectoral iris atrophy with minor rubeosis.

Zusammenfassung

An Albinokaninchen wurden verschiedene chirurgische Eingriffe durchgeführt, die eine Störung der Durchblutung des vorderen Augenabschnittes bewirken sollten. Fortlaufende klinische Beobachtung ergab in der Folgezeit ischaemische Schäden bis zur Nekrose. Die Bedeutung verschiedener chirurgischer Eingriffe für die resultierenden Komplikationen wird diskutiert. Die histopathologischen Untersuchungen ergaben ebenfalls ischaemische Veränderungen im vorderen Augenabschnitt, auch in Fällen, bei denen die biomikroskopische Untersuchung ohne pathologische Befunde zu sein schienen. Es handelte sich hierbei um Atrophie des Iris- und Ciliarkörpergewebes, Cataractbildung und Rubeosis iridis.

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Authors and Affiliations

  1. Clinical Institute for Experimental Ophthalmology, University of Bonn, Federal Republic of Germany

    Petja Vassileva, Miguel Kottow & Erich Weigelin

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  1. Petja Vassileva
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  2. Miguel Kottow
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  3. Erich Weigelin
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Fellows of the Alexander von Humboldt Foundation.

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Vassileva, P., Kottow, M. & Weigelin, E. Provoked iris ischaemia in the rabbit. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 231–238 (1975). https://doi.org/10.1007/BF00410034

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  • DOI: https://doi.org/10.1007/BF00410034

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