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Penetration of amikacin into the aphakic eye

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Summary

An experiment was designed to see if an aminoglycoside antibiotic, amikacin, would penetrate the vitreous of rabbits in greater concentrations in the postoperative aphakic eye than in the normal eye. Phakic and aphakic eyes were treated with amikacin by topical, subconjunctival, and intramuscular methods separately and combined. Bioassays of aqueous, anterior vitreous, and posterior vitreous revealed that concentrations of amikacin in ocular fluids after intramuscular administration were greater in the aphakic eye as compared to the normal eye; however, concentrations in the vitreous did not reach reliably bactericidal concentrations even when all three methods of administration were combined.

Zusammenfassung

Es wurde experimentell untersucht, ob das Aminoglykosid-Antibioticum Amikacin in den Glaskörper eines Kaninchens, bei dem operativ die Linse entfernt worden war, in größerer Konzentration eindringt als in den Glaskörper eines nicht operierten Auges. Das Antibioticum wurde aufgetropft, subkonjunctival oder intramuskular injiziert. Analysen des Kammerwassers, des vorderen und des hinteren Glaskörpers zeigen, daß die Amikacinkonzentration im aphaken Auge höher war als im nichtoperierten Auge. Die Glaskörperkonzentration erreicht jedoch nie ein verläßliches, bakterientötendes Ausmaß, auch wenn alle drei Applikationsmethoden kombiniert werden.

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Authors and Affiliations

  1. The Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Illinois

    Richard T. Kasbeer, Gholam A. Peyman, Donald R. May & Paul I. Homer

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  1. Richard T. Kasbeer
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  2. Gholam A. Peyman
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  3. Donald R. May
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  4. Paul I. Homer
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Additional information

This work was supported in part by a grant from Bristol Laboratories, in part by a grant from PHS-1107-03 and in part by Illinois Lions Club.

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Kasbeer, R.T., Peyman, G.A., May, D.R. et al. Penetration of amikacin into the aphakic eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 85–94 (1975). https://doi.org/10.1007/BF00410030

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