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Actual new cancer-causing hydrazines, hydrazides, and hydrazones

Aktuelle neue krebsverursachende Hydrazine, Hydrazide und Hydrazone

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Zusammenfassung

Zwanzig aktuelle neue krebsverursachende Hydrazine, Hydrazide und Hydrazone synthetischer oder natürlicher Herkunft werden beschrieben. Diese Substanzen induzieren bei Mäusen, Hamstern und Ratten Tumoren in verschiedenen Zielgeweben. Die Bevölkerung ist neun dieser Verbindungen in Form von Arzneimitteln, Herbiziden oder natürlich vorkommenden Inhaltsstoffen von eßbaren Pilzen ausgesetzt. Bis auf eine Ausnahme ist keines der hier beschriebenen Hydrazine auf krebsinduzierende Eigenschaften beim Menschen untersucht. Die Bevölkerung sollte vor der Verwendung dieser gefährlichen Substanzklasse, deren Gesamtzahl nun 40 Verbindungen umfaßt, gewarnt werden.

Summary

Twenty actual new cancer-causing hydrazines, hydrazides, and hydrazones of synthetic or natural origin are described. These compounds induce tumors in various target tissues in mice, hamsters, and rats. To nine of these compounds the human population is exposed in the form of drugs, agricultural herbicides, and naturally occurring ingredients of edible mushrooms. Yet, with one exception, none of the hydrazines described here were investigated for cancer-inducing abilities in man. The human population should be warned against the use of this hazardous class of chemicals, the total number of which is now 40.

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  1. The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 68105, Omaha, NE, USA

    B. Toth

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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest Editorials” on actual and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author. The Editors Die Zeitschrift “Journal of Cancer Research and Clinical Oncology” bringt in zwangloser Folge “Editorials” und “Guest Editorials” zu aktuellen und/oder kontroversen Problemen der experimentellen und klinischen Onkologie. Diese Beiträge geben ausschließlich die persönliche Meinung des Autors wieder. Die Herausgeber

This work was supported by Public Health Service contract NO1 CP05629 from the National Cancer Institute, NIH, USA

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Toth, B. Actual new cancer-causing hydrazines, hydrazides, and hydrazones. J Cancer Res Clin Oncol 97, 97–108 (1980). https://doi.org/10.1007/BF00409895

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