Summary
We have described the observation that Streptomyces griseus colonies grow group-wise on agar media containing streptomycin. We have found that this phenomenon is due to a substance (s) produced by germinating Str. griseus spores in media containing streptomycin, and this substance made the neighbouring spores more tolerant to increasing streptomycin concentrations. The substance is produced specifically by Str. griseus strains. The substance has probably a great molecular size, is thermolabile, not a nucleic acid and the applied enzymes did not inactivate it. Some investigated enzyme-poisons did not influence either its production or its effect on Str. griseus spores. We succeeded in carrying over the substance into liquid phase and separate it from the producing culture and this enables us to furterh purification and investigation of the substance.
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Vályi-Nagy, T., Szabó, G. Group-wise growth of Streptomyces in a medium containing streptomycin. Archiv. Mikrobiol. 27, 281–287 (1957). https://doi.org/10.1007/BF00409528
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DOI: https://doi.org/10.1007/BF00409528