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Locus B HLA antigens in psoriatic patients. Population and family studies and clinical relationship

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Summary

The HLA gene and haplotype frequencies in psoriatic population (N=136) and families (N=47) were estimated. The significant association with HLA-B17 and B13 was found. The relative risk for these antigens was 4.4 and 2.4, respectively. The most frequent haplotypes carrying the “psoriatic” antigens was HLA-A1, B17 and HLA-A10, B17, with significant relative risk, equalled 8.24 and 5.75. The distribution of HLA-B13 and B17 phenotypes according to the three groups of clinical activity and four groups of extent of skin lesions were considered. The strong association between HLA-B17 and psoriasis with large skin involvement (more than 50%) was observed. The possible role of antigen B17 in pathomechanism of psoriasis is discussed.

Zusammenfassung

Die HLA Gene und Haplotyp-Frequenzen einer psoriatischen Population (N=136) und Familien (N=47) wurden untersucht. Es wurde eine signifikante Assoziation mit HLA-B17 und B13 aufgefunden. Der Risikofaktor für diese Antigene war 4,4 bzw. 2,4. Die Haplotypen, die am häufigsten das psoriatische Antigen trugen, war HLA-A1, B17 und HLA-A10, B17 mit einem signifikanten Risiko von 8,24 und 4,75. Die Verteilung von HLA-B13 und B17-Phänotypen entsprechend der drei Gruppen klinischer Aktivität und vier Gruppen der Ausprägung der Hautveränderungen wurde berücksichtigt. Die ausgeprägte Assoziation zwischen HLA-B17 und Psoriasis mit großflächigem Hautbefall wurde in mehr als 50% festgestellt. Die mögliche Rolle des Antigens B17 im Pathomechanismus der Psoriasis wurde diskutiert.

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Authors and Affiliations

  1. Transplantation and Immunlogy Unit, Third Dept of Surgery, Nicolaus Copernicus Medical Academy, 16 Grzegórzecka, PL-31-531, Kraków, Poland

    G. Turowski

  2. Clinical Genetics Laboratory Institute of Pediatrics, Nicolaus Copernicus Medical Academy, 16 Grzegórzecka, PL-31-531, Kraków, Poland

    J. J. Pietrzyk

  3. Dept. of Dermatology, Stefan Żeromski's Hospital in Kraków, Poland

    M. Kapińska-Mrówka

Authors
  1. G. Turowski
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  2. J. J. Pietrzyk
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  3. M. Kapińska-Mrówka
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Supported by The Polish Academy of Sciences, grant no. 10.5

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Turowski, G., Pietrzyk, J.J. & Kapińska-Mrówka, M. Locus B HLA antigens in psoriatic patients. Population and family studies and clinical relationship. Arch Dermatol Res 271, 315–324 (1981). https://doi.org/10.1007/BF00409460

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  • DOI: https://doi.org/10.1007/BF00409460

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