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Human exposure to styrene

II. Quantitative and specific gaschromatographic analysis of urinary mandelic and phenylglyoxylic acids as an index of styrene exposure

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Summary

A simple and specific method for the quantitative gaschromatographic (GC) analysis of mandelic and phenylglyoxylic acid (MA and PGA), human urinary styrene metabolites, is described. MA is determined by trimethylsilylation and subsequent GC analysis. Because of difficulties involved in the direct determination of PGA due to the lack of quantitative and reproducible derivatization methods, this acid is reduced to MA prior to GC analysis. By a double determination with and without reduction both acids can be analyzed quantitatively. Both analysis show the same accuracy and precision and can therefore be intercorrelated accurately.

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Authors and Affiliations

  1. Département d'hygiène industrielle, Institut universitaire de médecine sociale et préventive, Rue César-Roux 18, CH-1005, Lausanne, Switzerland

    M. Guillemin

  2. Arbeitsärztlicher Dienst des Bundesamtes für Industrie, Gewerbe und Arbeit, CH-8000, Zürich, Switzerland

    D. Bauer

Authors
  1. M. Guillemin
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  2. D. Bauer
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Guillemin, M., Bauer, D. Human exposure to styrene. Int. Arch Occup Environ Heath 37, 57–64 (1976). https://doi.org/10.1007/BF00409364

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  • DOI: https://doi.org/10.1007/BF00409364

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