Summary
Two lymphocyte subpopulations, T cells bearing a receptor for the Fc fragment of IgG (Tγ) and theophylline-sensitive T cells, were investigated in 49 patients with allergic contact dermatitis (ACD) in the acute phase and compared with a control group. Patients with ACD had markedly reduced relative Tγ and theophylline-sensitive T lymphocyte levels, compared with normals (P<0.0005). The patients also showed reduced absolute Tγ and theophylline-sensitive T cells with respect to the controls (P<0.01).
To determine whether decreased levels of Tγ and theophylline-sensitive T cells were related to the activity of ACD, the same T-cell subsets were determined in 10 of 49 patients after the clearing of the contact dermatitis. Both T-cell subpopulations were found within the normal range.
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Angelini, G., Vena, G.A., D'Ovidio, R. et al. Tγ and theophylline-sensitive T lymphocytes in allergic contact dermatitis. Arch Dermatol Res 273, 241–246 (1982). https://doi.org/10.1007/BF00409252
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DOI: https://doi.org/10.1007/BF00409252