Summary
Twelve cases of “preludin” intoxication are described. The physical signs included mydriasis, impaired pupillary response to light and even impaired reaction to accomodation-convergence. Tremor of the tongue and upper limb together with augmented tendon reflexes and facial twitching were noted. Excessive small movements of the hands and touching of the face occurred against a background of generalized overactivity. Mood changes included lability or depression associated with depressive delusions. Paranoid ideas were present in eight subjects, while five had auditory hallucinations. Disorientation, impaired attention and concentration with loss of insight were also encountered. All abnormalities abated within 14 days of drug withdrawal.
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Bartholomew, A.A., Marley, E. Toxic response to 2-phenyl-3-methyl tetrahydro-1, 4-oxazine hydrochloride “preludin” in humans. Psychopharmacologia 1, 124–139 (1959). https://doi.org/10.1007/BF00409112
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DOI: https://doi.org/10.1007/BF00409112