A study of the interaction of electroconvulsive shock with chlorpromazine and reserpine in rats

Summary and Conclusion

A study was conducted to determine the interactive effects of electroconvulsive shock with chlorpromazine and reserpine in rats. Five dose levels for each of the drugs were examined and compared with appropriate control conditions. These effects were studied with the subjects in an atmosphere of 95 per cent O₂ + 5 per cent CO₂ as well as under normal atmospheric conditions.

The results of this experiment are presented graphically and analyzed statistically. The results of the analysis indicate the following:

• 1. A synergic relationship is obtained when ECS is administered in conjunction with either reserpine or chlorpromazine in rats. The dependent variable used to measure this interaction was the mortality rate for the various groups during or immediately subsequent to ECS procedures. This finding is in agreement with the results of previous studies from this laboratory.

• 2. A stepwise function is obtained when reserpine is paired with ECS. The first critical dosage occurs below the 0.0026 mg/gm of body weight level and the second within the 0.014 to 0.0130 mg/gm range.

• 3. The joint administration of chlorpromazine and ECS results in a function that is asymptotic within the 0.0026 mg/gm to 0.0130 mg/gm range.

• 4. When an atmosphere of 95 per cent O₂ + 5 per cent CO₂ is made available to an animal immediately prior to and during ECS procedures, there is a significant reduction in the probability of death.