Summary
The authors sought to develop knowledge of the characteristics of different types of psycholeptic drugs. Using 18 normal voluntary subjects, and psychometric methods, the authors experimentally compared the effects of the following: a dose of 100 mg of chlorpromazine (neuroleptic), a dose of 300 mg of amobarbital (hypnotic) and a placebo.
The psychophysiological measures and intelligence tests showed that with the 2 drugs there was a particulary noticeable deficit in the most elementary of sensori-motor functions but only a negligible deficit of intellectual functions. On the other hand with the personality test used (MMPI), it was found that chlorpromazine had practically no effect whereas amobarbital brought about limited but distinct changes in the profile and particularly on the Ma, Sc and Mf scales. It is not possible to interpret precisely such modifications in the responses of subjects asked to describe their feelings and behaviour.
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Bibliographie
Nicolas-Charles, P. J.: Comparaison psycho-physiologique et psychométrique d'un hypnotique et d'un neuroleptique (Amobarbital et Chlorpromazine) sur des sujets normaux en situation expérimentale. Etude pharmacologique et perspectives cliniques. Thèse Paris 1958. (200 p. Multigr.) Nous donnons simplement ci-dessous la référence des principaux travaux psycho-pharmacologiques et celle des tests utilisés.
Arkola, A.: An experimental study of the effects of sodium amytal upon performance on the Hunt Minnesota Test for organic brain damage. J. clin. Psychol. 3, 392–396 (1947).
Berg, O.: A study of the effect of evipan on the flicker fusion intensity in brain injuries. Acta psychiat. scand. Suppl. 58 (1949).
Cohen, L., R. Sears and W. Shipley: Psycho-psychiological measurements during somnolence induced by phenobarbital (Luminal). J. gen. Psychol. 10, 415–431 (1934).
Delay, J.: Allocution finale au colloque international sur la chlorpromazine Encéphale 45, 1181 (1956).
—, P. Deniker, Y. Tardieu et T. Lempérierè: Médicaments et cures ≪neuroleptiques≫ en thérapeutique psychiatrique. Presse méd. 63, 663–665 (1955).
Eysenck, H., and W. Rees: States of heightened suggestibility: narcosis. J. ment. Sci. 91, 301–310 (1945).
Grunewald, K.: Effect of Evipan on the reaction times for light and sound in mental disorders. Acta psychiat. scand. 29, 365–368 (1954).
Heimann, P., u. P. N. Witt: Die Wirkung einer einmaligen Largactilgabe bei Gesunden. Mschr. Psychiat. Neurol. 129, 104–123 (1955).
Hill, H. E., R. E. Belleville and A. Wikler: Motivationnal determinants in modification of behaviour by morphine and pentobarbital. A.M.A. Arch. Neurol. Psychiat. 77, 1 (1957).
Ideström, C. M.: Flicker fusion in chronic barbiturate usage: a quantitative study in the pathophysiology of drug addiction. Acta psychiat. scand. Suppl. 91, 93 (1954).
Kornetsky, C.: Psychological effects of chronic barbiturate intoxication A.M.A. Arch. Neurol. Psychiat. 65, 557–567 (1951).
Landis, C., and J. Zubin: The effect of thonzylamine hydrocloride and phenobarbital sodium on certain psychological functions. J. Psychol. (Provincetown) 31, 181–200 (1951).
Lehman, H. E., and J. Csank: Differential screening of phrenotropic agents in man; Psychophysiologic tests data. J. clin. exp. Psychopath., Sept. 1957.
Lindemann, E.: Psychological changes in normal and abnormal individuals under the influence of sodium amytal. Amer. J. Psychiat. 88 (1), 1083–1091 (1932).
Muecher, H.: Contribution psychologique à l'étude des effets des barbituriques. I: Analyse de l'activité imaginative systématiquement induite. Psychol. Beitr. 1, 81–117 (1953).
Ohler, W.: Wirkung kleiner Veronaldosen auf die Arbeitskurve am Ergographen. Z. ges. Neurol. Psychiat. 136, 299–310 (1931).
Peter, H.: Alkohol und Sedative. Dtsch. Z. ges. gerichtl. Med. 30, 113–154 (1939).
Roubleff, I.: Exploration pharmacodynamique de la personnalité des sujets normaux et des schizophrènes. Etude comparative au moyen du test de Rorschach. Thèse Paris 1949.
Sargant, W., P. Slater and H. Halstead: Effects of Alcohol and Sodium Amytal on Intelligence Test Score. J. exp. Psychol. 23, 545–552 (1938).
Sutter, J. M., et G. Pascalis: Effets psychologiques de la chlorpromazine. Encéphale 45, 979–986 (1956).
Trent, S. E.: Narcosis and visual contour clarity. J. gen. Psychol 36, 65–78 (1947).
Warshaw, L., R. Leiser and S. Izner: The clinical significance and theory of sodium amytal Rorschach testing. J. prof. Techn. 18, 248–251 (1954).
Weinstein, E., and S. Malitz: Changes in symbolic expression with amytal sodium. Amer. J. Psychiat. 111, 198–206 (1954).
Bibliographie technique
Les tests de Benton (Visual R tention Test), de Cattell (Culture Free test) et de Porteus (Maze Test), ainsi que le M.M.P.I. (Minnesota Multiphasic Personality Inventory) ont été utilisés dans l'édition française publiée par le Centre de Psychologie Appliquée — Paris.
Robinson, M. F.: Personality changes after psychosurgery. In W. Freeman et J. Watts, Psychosurgery in the treatment of mental disorders and intractable pain. 1 vol. Springfield: Ch. C. Thomas ed. 1950.
Welsh, G. S.: An anxiety index and an internalization ratio for the M.M.P.I. J. cons. Psychol. 16, 65–72 (1952).
Williams, H. L.: The development of a caudality scale. J. clin. Psychol. 8, 293–298 (1952).
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Delay, J., Pichot, P., Nicolas-Charles, P. et al. Etude psychométrique des effets de l'amobarbital (amytal) et de la chlorpromazine sur des sujets normaux. Psychopharmacologia 1, 48–58 (1959). https://doi.org/10.1007/BF00408111
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DOI: https://doi.org/10.1007/BF00408111