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Anterior segment reactions after experimental trauma to rabbit eyes

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The effect of experimentally induced uniocular trauma was investigated in the adult albino rabbit by means of iris fluorescein angiography. Paracentesis, blunt trauma, occlusion of all four vortex veins or of the two long posterior ciliary arteries, or local instillation of nitrogen mustard, were performed in a number of animals, some of which received systemic aspirin preoperatively. Iris angiograms of the injured and the contralateral eye were performed immediately after the traumatic insult.

The injured eye always showed an increased permeability to fluorescein. Except for paracentesis, the ipsilateral response often included ischemia of the iris. The contralateral eye always showed an increase in fluorescein permeability into the aqueous. In some cases, sector ischemia of the contralateral iris was seen. Aspirin inhibited some ipsilateral responses but had no effect on the consensual reactions.

It is concluded that ipsilateral trauma almost invariably causes a contralateral reaction in the rabbit eye, which is more severe if the injury creates ischemia of the iris. Since these reactions are inefficiently blocked by aspirin, they are not prostaglandin-mediated. The interocular pathway involved may be neural or vascular in nature.

Zusammenfassung

Die Reaktionen nach experimentell verursachten, unterschiedlichen einseitigen Augentraumen wurden beim erwachsenen Albinokaninchen mittels Fluoreszenzangiographie der Iris untersucht.

Alle verletzten Augen zeigten eine erhöhte Fluoresceindurchlässigkeit der Gefäße des Vorderabschnitts. Oft war ipsilateral auch eine Durchblutungsminderung der Iris zu sehen. Die kontralateralen Augen zeigten regelmäßig eine erhöhte Farbstoffdurchlässigkeit im Kammerwasser. Diese konsensuelle Reaktion war unterschiedlich stark, und wurde in einigen Fälle von Sektorenischämie der Iris begleitet. Aspirin hemmte zum Teil die ipsilaterale Reaktion, ohne das kontralaterale Auge zu beeinflussen.

Anhand dieser Ergebnisse kann auf eine konsensuelle Reaktion nach einäugigem Trauma geschlossen werden. Sie ist besonders dann ausgeprägt, wenn das Trauma eine Ischämie der Iris zur Folge hat. Da diese Reaktionen durch Aspirin nur gering verringert werden konnten, wird vermutet daß Prostaglandine nicht für die konsensuellen Reaktionen verantwortlich sind. Sie scheinen eher durch neurale oder vaskuläre Mechanismen ausgelöst und vermittelt zu werden.

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  1. Charlottenklinik für Augenkranke, Elisabethenstr. 15, D-7000, Stuttgart 1, Germany

    Michael Kottow

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  1. Michael Kottow
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Kottow, M. Anterior segment reactions after experimental trauma to rabbit eyes. Albrecht von Graefes Arch. Klin. Ophthalmol. 209, 125–135 (1978). https://doi.org/10.1007/BF00407845

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  • DOI: https://doi.org/10.1007/BF00407845

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