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Use of tobramycin in eradicating experimental bacterial endophthalmitis

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

A study of intravitreal injection of tobramycin sulfate in the treatment of experimental Pseudomonas aeruginosa endophthalmitis in rabbits resulted in the following findings: (1) A dose of 750 μg per 0.1 ml was nontoxic to ocular structures. (2) 500 μg of tobramycin sulfate remained bactericidal in both aqueous and vitreous humors for at least 96 hours. (3) Eyes cleared if treated with intravitreal injection of 500 μg tobramycin sulfate seven hours after bacterial inoculation, while only 2 of 5 eyes treated ten hours after inoculation showed complete clearing. (4) Systemic and subconjunctival administration of antibiotic failed to eradicate infection in 10 eyes.

Zusammenfassung

An Kaninchen wurde eine durch Pseudomonas aeruginosa erzeugte Endophthalmitis mit intravitrealer Injektion von Tobramycinsulfat behandelt. Hierbei blieb eine Dosis von 750 μg auf 0,1 ml ohne toxische Wirkung auf die intraocularen Gewebe. Die Konzentration von 500 μg erwies sich im Kammerwasser und im Glaskörper für mindestens 96 Stunden bactericid. Wenn 7 Std nach der Einimpfung der Bakterien 500 μg Tobramycin in den Glaskörper injiziert wurden, heilten alle Augen. Hingegen traf dies nur für 2 von 5 Augen zu, wenn dies erst nach 10 Std geschah. Allgemeine und subconjunctivale Anwendung von Tobramycin konnte das Angehen einer Entzündung in 10 Augen nicht verhindern.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Illinois

    Thomas O. Bennett & Gholam A. Peyman

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  1. Thomas O. Bennett
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  2. Gholam A. Peyman
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Supported by a grant from the Eli Lilly Company, Indianapolis, Indiana and in part by a grant from the National Institutes of Health, PHS EY 1107-01.

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Bennett, T.O., Peyman, G.A. Use of tobramycin in eradicating experimental bacterial endophthalmitis. Albrecht v. Graefes Arch. klin. exp. Ophthal. 191, 93–107 (1974). https://doi.org/10.1007/BF00407823

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  • DOI: https://doi.org/10.1007/BF00407823

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