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Über den Einfluß von Corticosteroiden auf die fibrinolytische Aktivität verschiedener Gewebe des Auges

The influence of corticosteroids on the fibrinolytic activity in different tissues of the eye

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Abstract

The influence of corticosteroids on the fibrinolytic activity in different tissues of the eye was investigated. Rats were treated with corticosteroids, and the fibrinplate method of Todd (1962) was used to estimate the fibrinolytic activity. After 14 days treatment with corticosteroids the fibrinolytic activity decreased. In the control eyes no fibrinolytic activity was left after 6 h of autolysis. The eyes treated with corticosteroids, however, still had fibrinolytic activity.

Zusammenfassung

Anhand von Ratten, die mit verschiedenen Corticosteroiden behandelt wurden, wurde deren Einfluß auf die fibrinolytische Aktivität verschiedener Gewebe des Auges untersucht. Es wurde dabei die Fibrinplättchenmethode nach Todd verwendet. Nach 14tägiger Corticosteroidapplikation war die fibrinolytische Aktivität deutlich vermindert. Nach 6stündiger Autolyse des Gewebes war bei den Kontrollen kaum noch fibrinolytische Aktivität nachzuweisen; dagegen zeigten die Augen mit Corticosteroidbehandlung noch deutliche fibrinolytische Aktivität.

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Literatur

  • Allan R, Goldberg BA, Lefebvre WP (1975) Plasminogenactivators of transformed and normal cells. In: Cold Spring Harbour Conferences of Cell Proliferation, Vol 2:849–856

    Google Scholar 

  • Ambrus JL (1966) Pharmacology Society Symposion: The Fibrinolysis System. Rep Fed Proc 25:42–51

    Google Scholar 

  • Astrup T, Müllertz S (1952) The fibrin-plate-method for estimating fibrinolytic activity. Arch Biochem 40:346–351

    PubMed  Google Scholar 

  • Blasini R, Haas-Denk S, Kriegelsteiner P, Wriedt-Lübbe J, Erhardt W (1977) Erfassung gewebeständiger Inhibitoren gegen Plasmin und ihre Beeinflussung durch Betamethason und Ambroxol. Med Welt 28(NF): 1392–1394

    Google Scholar 

  • Forrester CR, Prentice M, Williamson J, Forbes CD (1974) Fibrinolytic activity of the vitreous body. Invest Opthalmol Vis Sci 875–879

  • Pandolfi M, Kwaan HC (1967) Fibrinolysis in the anterior segment of the eye. Arch Ophthalmol 77:99–104

    PubMed  Google Scholar 

  • Pandolfi M, Astrup T (1966) Effect of plasmin on outflow resistance in the primate eye. Proc Soc Exp Biol Med 121:139–142

    PubMed  Google Scholar 

  • Pandolfi M, Coccheri S, Astrup T (1962) Thromboplastic and fibrinolytic activities in tissues of the eye. Proc Soc Exp Biol Med 109:159–161

    PubMed  Google Scholar 

  • Pandolfi M (1967) Fibrinolysis and outflow resistance in the eye. Am J Opthalmol 64:1141–1148

    Google Scholar 

  • Rohen JW, Linnér E, Witmer R (1973) Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid glaucoma. Exp Eye Res 17:19–31

    Article  PubMed  Google Scholar 

  • Rohen JW (1964) Das Auge und seine Hilfsorgane. In: Handbuch der mikroskopischen Anatomie des Menschen, Bd III/4, Springer Berlin, Göttingen, Heidelberg, New York

    Google Scholar 

  • Saiduzzafar H (1970) Tissue fibrinolytic activity in the anterior segment of the eye as related to aqueous outflow. Exp Eye Res 10:297–301

    PubMed  Google Scholar 

  • Thompson EB (1979) Glucocorticoids and lysosomes. In: glucocorticoid hormone action. Ed by JO Baxler and GG Rousseau. In: Monographs on Endocrinology, Vol 12, Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Todd AS (1964) Localization of fibrinolytic activity in tissues. Brit Med Bul 20:210–212

    PubMed  Google Scholar 

  • Todd AS (1962) Histological localization of fibrinolysin activator. 3. Path Bacteriol 78:281–283

    Google Scholar 

  • Wigler M, Ford JP, Weinstein JB (1975) Glucocorticoid inhibition of the fibrinolytic activity of tumor cells. In: Cold Spring Habour Conferences of Cell Proliferation, Vol 2:849–856

    Google Scholar 

Download references

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Authors and Affiliations

  1. Anatomisches Institut der Universität Erlangen-Nürnberg, Krankenhausstr. 9, D-8520, Erlangen, Bundesrepublik Deutschland

    H. W. Arnold

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  1. H. W. Arnold
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Frau K. Pantel möchte ich an dieser Stelle für die Hilfe bei der Herstellung der Mikrophotos danken.

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Arnold, H.W. Über den Einfluß von Corticosteroiden auf die fibrinolytische Aktivität verschiedener Gewebe des Auges. Albrecht von Graefes Arch. Klin. Ophthalmol. 216, 77–84 (1981). https://doi.org/10.1007/BF00407780

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  • DOI: https://doi.org/10.1007/BF00407780

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