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Some effects of adiphenine, benactyzine, and chlorpromazine upon several operant behaviors

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Summary

Adiphenine, benactyzine, and chlorpromazine were studied in four tests of operant behavior: a fixed interval schedule of reinforcement, a variable interval schedule, avoidance conditioning, and a conditioned emotional response. Adiphenine was essentially inactive under all conditions studied. Benactyzine exhibited both rate-increasing and ratedecreasing activity, depending on the dose, the time after administration, and the behavioral test. Chlorpromazine showed a consistent depressant action in all tests, following the usual dose-response relationship.

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Author notes

  1. John J. Boren

    Present address: Walter Reed Army Institute of Research, Washington 12, D.C.

Authors and Affiliations

  1. Merck Institute for Therapeutic Research West Point, Pennsylvania

    John J. Boren

  2. Dept. of Psychology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington 12, D.C., USA

    John J. Boren

Authors
  1. John J. Boren
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Additional information

A slightly modified version of this paper was presented at the 1956 fall meetings of the American Society for Pharmacology and Experimental Therapeutics.

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Boren, J.J. Some effects of adiphenine, benactyzine, and chlorpromazine upon several operant behaviors. Psychopharmacologia 2, 416–424 (1961). https://doi.org/10.1007/BF00407440

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  • DOI: https://doi.org/10.1007/BF00407440

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