Abstract
A quantitative EEG study in volunteer adults was undertaken to distinguish single oral administrations of 50 and 100 mg amobarbital, 10 mg dextroamphetamine, 40 mg fenfluramine and placebo. Four hour EEG recordings were monitored by frequent auditory reaction time tasks. The EEG changes were measured by digital computer period analysis.
In the analysis, each drug was distinguished from placebo, and from each other, with the best discriminations for 50 mg amobarbital and dextroamphetamine, and the poorest discrimination of fenfluramine from 50 mg amobarbital.
These observations are consistent with the clinical pharmacology of the compounds and suggest further applications of quantitative EEG for the classification of psychoactive drugs.
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Aided, in part, by USPHS grants MH-11358, 13003 and 13358; the Psychiatric Research Foundation of Missouri, Smith Kline and French Laboratories and A. H. Robins, Inc.
This report summarizes data of a second quantitative EEG study undertaken in 1965–1966. Earlier progress reports dated April 1965 and May 1967 are available.
The cooperation of Connie Hickman, B.S.E.E. and the nursing and technical staff of the Missouri Institute of Psychiatry are gratefully acknowledged.
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Fink, M., Shapiro, D.M. & Itil, T.M. EEG profiles of fenfluramine, amobarbital and dextroamphetamine in normal volunteers. Psychopharmacologia 22, 369–383 (1971). https://doi.org/10.1007/BF00406875
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DOI: https://doi.org/10.1007/BF00406875