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Infrared-spectroscopic determination of the water content of the horny layer in healthy subjects and in patients suffering from atopic dermatitis

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Summary

Infrared spectroscopic measurements of hydration of the stratum corneum before and after stripping the skin five and ten times with scotch tape are reported. Investigations on 64 healthy persons show that for individuals over 45 and under 15 years of age the range of the measurement values is strikingly larger than for persons in the age group 15–45 years of age. A small, but not significant reduction in the measurement values is found in females as compared to males. A comparison of the clinically unaffected skin of atopic dermatitis patients with the skin of normal persons points to an increase in the hydration of the stratum corneum of atopic dermatitis patients, which is especially evident in patients who show clinical evidence of “dry” and rough skin.

Zusammenfassung

Es wird über infrarotspektroskopische Messungen der Hornschichtfeuchtigkeit vor und nach fünf bzw. zehnmaligen Tesafilmabrissen berichtet. Untersuchungen an 64 gesunden Probanden lassen erkennen, daß bei Personen über 45 und unter 15 Jahren die Streuung der Meßwerte erheblich größer ist als in den dazwischenliegenden Altersstufen. Bei den weiblichen Versuchspersonen ist eine geringe, nicht signifikante Reduktion der Meßwerte im Vergleich zu den männlichen Personen erkennbar. Beim Vergleich der klinisch nicht erkrankten Haut von Neurodermitikern und der Haut von Gesunden ergibt sich ein Hinweis auf eine Erhöhung des Wassergehaltes der Hornschicht bei den Neurodermitikern, die besonders die Neurodermitiker betrifft, die klinisch eine “trockene” und rauhe Haut aufweisen.

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Supported by the Deutsche Forschungsgemeinschaft (grant Gl 91/4)

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Gloor, M., Heymann, B. & Stuhlert, T. Infrared-spectroscopic determination of the water content of the horny layer in healthy subjects and in patients suffering from atopic dermatitis. Arch Dermatol Res 271, 429–436 (1981). https://doi.org/10.1007/BF00406688

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