Skip to main content
SpringerLink
Log in

Dialysis for psoriasis —Preliminary remarks concerning mode of action

  • Original Contributions
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

In one patient treated by peritoneal dialysis for psoriasis the skin lesions cleared completely. In two persons hemodialysis gave unsatisfactory results.

In treated and another three untreated patients cellular immunity was evidently suppressed. This phenomenon is similar to the immunologic changes in persons with uremia.

Solutes in middle molecular weight range (SMMWR) suppress cellular immunity. These compounds were therefore investigated in psoriatics. The level of SMMWR was lower before than after each dialysis, although their concentration increased slightly during the dialytic treatment.

This suggests that solutes in middle molecular weight are fixed in the epidermis and/or in the walls of the skin capillaries and that dialysis liberates them from these places.

Peritoneal dialysis seems to be a more effective method of treating psoriasis than hemodialysis. Solutes in middle molecular weight range might play an important role in the pathomechanisms of this multifactorial disease.

Zusammenfassung

Bei einem Patienten, der mit der peritonealen Dialyse behandelt wurde, heilten die psoriatischen Herde völlig ab. Bei zwei weiteren Patienten waren die Resultate nicht befriedigend. Bei den behandelten und den drei nicht behandelten Patienten war die celluläre Immunität augenscheinlich unterdrückt. Dieses Phänomen ist mit den immunologischen Veränderungen bei Personen mit einer Urämie zu vergleichen. Organische Verbindungen von mittlerem Molekulargewicht, wozu auch die Gruppe der urämischen Toxine gehört, unterdrücken die celluläre Immunität. Deshalb wurden diese Verbindungen bei Psoriatikern untersucht. Der Spiegel der SMMWR war vor jeder Dialyse tiefer als danach, obwohl deren Konzentration während der Dialysebehandlung leicht anstieg. Dies läßt vermuten, daß diese SMMWR-Substanzen in der Epidermis fixiert sind oder im Bereiche der Capillaren vorliegen und dementsprechend während der Dialyse von diesen Orten freigesetzt werden.

Die Peritonealdialyse scheint mehr eine wirksamere Behandlungsmethode der Psoriasis zu sein als die Hämodialyse. SMMWR-Substanzen können eine wichtige Rolle in dem Pathomechanismus der multifaktoriellen Erkrankung darstellen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Anderson P (1978) Dialysis for psoriasis. Artif Organs 2:202

    PubMed  Google Scholar 

  2. Anderson P (1979) Progress concerning dialysis of psoriatics. Artif Organs 3:382

    PubMed  Google Scholar 

  3. Buselmeier T, Nelson R, Bentley R, Dungey R, Kjellstrand C (1979) Dialysis treatment of psoriasis. Dial Transpl 8:568

    Google Scholar 

  4. Chugh K, Bushan K, Kher V (1980) Remission of psoriasis with hemodialysis. XVII. Congr Eur Dial Transplant Assoc, Prague (Abstract 21)

  5. Cichocki T, Hanicki Z, Komorowska Z, Sułowicz W, Klein A (1980) The influence of solutes in middle molecular weight range from dialysate on the migration rate leucocytes. Kidney Int 17:231

    Google Scholar 

  6. Epstein W (1971) Immunologic factors in psoriasis. Proc Int Symp 287

  7. Gliński W, Haftek M, Obałek S, Jabłońska S (1978) Cell-mediated immunity (CMI) in psoriasis. Arch Immunol Ther Exp (Warsz) 26:755

    Google Scholar 

  8. Gliński W, Jabłońska S, Jarzabek-Chorzelska M, Zarębska Z, Imiela J, Nosarzewski J (1979) Continous peritoneal dialysis for treatment of psoriasis. Arch Dermatol Res 266:83

    PubMed  Google Scholar 

  9. Gliński W, Jabłońska S, Imiela J, Nosarzewski J, Jarząbek-Chorzelska M, Haftek M, Obałek S (1979) Continous peritoneal dialysis for treatment of psoriasis. I. Depletion of PMNL as a possible factor for clearing of psoriatic lesions. Arch Dermatol Res 265:337

    PubMed  Google Scholar 

  10. Gombos E, Jefferson D, Bhat J (1975) Effect of haemodialysis on immune response. Proc Eur Dial Transplant Assoc 11:365

    Google Scholar 

  11. Goulhou J, Menadier J, Clot J (1978) New concepts in the pathogenesis of psoriasis. Br J Dermatol 98:585

    PubMed  Google Scholar 

  12. Hanicki Z, Sarnecka-Keller M, Klein A, Slizowska Z (1974) Middle-sized ninhidrin-positive molecules in uraemic patients treated by repeated haemodialysis. Clin Chim Acta 54:47

    Article  PubMed  Google Scholar 

  13. Hanicki Z, Cichocki T, Komorowska Z, Sułowicz W, Smoleński O (1979) Some aspects of cellular immunity in untreated and on maintenance hemodialysis patients. Nephron 23:273

    PubMed  Google Scholar 

  14. Hanicki Z, Cichocki T, Sarnecka-Keller M, Klein A, Komorowska Z, Smoleński O (1976) Influence of middle-sized molecules aggregates from dialysate of uremic patients on lymphocyte transformation in vitro. Nephron 17:73

    PubMed  Google Scholar 

  15. Klein A, Sarnecka-Keller M, Hanicki Z (1978) Middle-sized ninhidrin-positive molecules in uraemic patients treated by repeated haemodialysis. Clin Chim Acta 90:7

    Article  PubMed  Google Scholar 

  16. Mastrangelo F, Lamperi S, Buocristiani U, Binazzi M, Carrozzi S, Rizzelli S (1980) About mechanism of dialytic effect on psoriasis. XVII. Congr Eur Dial Transplant Assoc, Prague (Abstract 67)

  17. McEnvoy J, Kelly A (1976) Psoriatic clearence during hemodialysis. Ulster Med J 45:76

    PubMed  Google Scholar 

  18. Maeda K, Saito S, Kawaguchi R, Niwa T, Kobayashi K, Ohta K, Asada A (1979) Chemical analysis of the nails of patients with psoriasis treated with dialysis. Artif Organs 3:27

    PubMed  Google Scholar 

  19. Mustin H, Conceicao S (1978) Remission of psoriasis during hemodialysis. Br Med J 1:480

    PubMed  Google Scholar 

  20. Mustin H, Conceicao, K, Rubin J (1978) Peritoneal dialysis in psoriasis. Ann Intern Med 88: 349

    PubMed  Google Scholar 

  21. Missenson A, Rapaport M, Gordon A, Norius R (1979) Hemodialysis in the treatment of psoriasis — a control study. Ann Intern Med 91:218

    PubMed  Google Scholar 

  22. Rubisz-Brzezińska J, Koziak H, Szczeklik Franek A, Suchan L, Właszczuk-Szulc H (1980) Hemodialysis in psoriasis (in Polish). Pol Tyg Lek 35:129

    PubMed  Google Scholar 

  23. Peserico A (1979) Development of psoriasis during dialysis. Arch Dermatol 115:1169

    Article  Google Scholar 

  24. Sprenger-Klasen L, Franz H, Rodermund O (1980) Besserung der Psoriasis durch Hämodialyse. Dtsch Med Wochenschr 105:925

    PubMed  Google Scholar 

  25. Twardowski Z (1977) Abatement of psoriasis and repeated dialysis. Ann Intern Med 86:509

    Google Scholar 

  26. Twardowski Z (1979) Epidermopoetin-hypothetic factor of psoriasis (in Polish). Przegl Dermatol 66:103

    PubMed  Google Scholar 

  27. Twardowski Z, Nolph K, Rubin J (1978) Peritoneal dialysis for psoriasis. Ann Intern Med 88: 349

    PubMed  Google Scholar 

  28. Wei-Tzuoh Chen, Hu H, Schiltz J, Nakamoto S (1978) In search of “psoriasis” factor(s): a new approach by extracorporeal treatment. Artif Organs 2:203

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, Academy of Medicine, Kopernika 15, PL-31-501, Kraków, Poland

    Z. Hanicki & O. Smoleński

  2. Dept. of Histology, Academy of Medicine, Kopernika 7, PL-31-034, Kraków

    T. Cichocki & W. Sułowicz

  3. Institute of Molecular Biology, Jagiellonian University, Grodzka 54, PL-31-044, Kraków

    A. Klein

  4. Dept. of Dermatology, Academy of Medicine, Kopernika 19, PL-31-501, Kraków

    J. Czabanowska

Authors
  1. Z. Hanicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Cichocki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. Smoleński
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Sułowicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Czabanowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanicki, Z., Cichocki, T., Klein, A. et al. Dialysis for psoriasis —Preliminary remarks concerning mode of action. Arch Dermatol Res 271, 401–405 (1981). https://doi.org/10.1007/BF00406684

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00406684

Key words

Schlüsselwörter

Search

Navigation