Summary
The study of the relationship between HLA antigens and scleroderma shows an increase of antigens HLA A9 and DR3 in patients with a relative risk of 12.18 if both antigens are present in the same patient.
The presence of HLA A9 or DR3 is neither related to organ involvement nor to immunologic changes.
Zusammenfassung
Die Untersuchung der Beziehungen zwischen HLA-Antigenen und Sklerodermie zeigt eine Erhöhung der Antigene HLA A9 und DR3 bei Patienten mit einem relativen Risiko von 12,18, wenn beide Antigene beim gleichen Patienten vorhanden sind.
Das Vorhandensein der HLA A9 und DR3 zeigt weder Beziehungen zu Störungen der inneren Organe noch zu immunologischen Veränderungen.
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References
Clements PJ, Opelz G, Terasaki PJ, Mickey HR, Furst D (1978) Association of HLA antigen A9 with progressive systemic sclerosis (scleroderma). Tissue Antigens 11:357–361
Hughes P, Gelsthorpe K, Doughty RW, Rowell NR, Rosenthal FD, Sneddon JB (1978) The association of HLA-B8 with visceral disease in systemic sclerosis. Clin Exp Immunol 31:351–356
Masters R, Hood AF, Cosini B (1975) Chronic cutaneous graft versus host reaction following bone marrow transplantation. Arch Dermatol 111:1526
Moens H, Farid NR (1978) Hasimoto's thyroiditis is associated with HLA-DRw3. N Engl J Med 299:133–134
Rabin BS, Rodnan GP, Bassion S, Gill TJ (1975) HLA antigens in progressive systemic sclerosis (scleroderma). Arthritis Rheum 18:381–382
Rees AJ, Peters DK, Compston DAS, Batchelor JR (1978) Strong association between HLA-DRw2 and antibody-mediated Goodpasture's syndrome. Lancet I:966–968
Stastny P (1978) Association of B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298:869–871
Svejgaard A, Dausset J (1977) Editors in HLA and disease. Munksgaard, Copenhagen
Tan EM, Rodnan GP (1975) Profile of antinuclear antibodies in progressive systemic sclerosis (P.SS.) Arthritis Rheum 18:430
Terasaki PI (1980) Histocompatibility testing. UCLA, Los Angeles, CA
Tuffanelli DL, Winkelman RK (1962) Scleroderma and its relationship to the “collagenosis” dermatomyositis, lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome. Am J Med Sci 243:133
van Vloten WA, Scheffer ES, Dooren LJ (1977) Localized scleroderma-like lesions after bone marrow transplantation in man. Br. J Dermatol 96:337–341
Woolf B (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19:251–253
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Ercilla, M.G., Arriaga, F., Gratacós, M.R. et al. HLA antigens and scleroderma. Arch Dermatol Res 271, 381–385 (1981). https://doi.org/10.1007/BF00406682
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DOI: https://doi.org/10.1007/BF00406682