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Effects of Cannabis sativa (marihuana) on the fighting behavior of mice

Summary

Alcoholic extracts of 2 different samples of Cannabis sativa (marihuana) have been tested for activity on isolation-induced aggressive behavior and on spontaneous motor activity of mice, and on corneal areflexia in rabbits.

Both extracts were found to be active in suppressing aggressiveness, and extract N (marihuana from the northeast of Brazil) was found to be 15 times as potent as extract W (marihuana from the west of Brazil). On the other hand, both extracts showed the same activity when assayed by the corneal areflexia method in rabbits. The amount of extract N that produced 50 per cent abolition of isolation-induced aggressiveness was far less than that necessary to reduce the motor activity of the mice.

The discrepancy in potency of the extracts when assayed by both methods, seems to indicate that different active principles are involved in the reduction of aggressive behavior of mice and in producing corneal areflexia in rabbits.

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Santos, M., Sampaio, M.R.P., Fernandes, N.S. et al. Effects of Cannabis sativa (marihuana) on the fighting behavior of mice. Psychopharmacologia 8, 437–444 (1966). https://doi.org/10.1007/BF00406492

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Keywords

  • Aggressive Behavior
  • Motor Activity
  • Active Principle
  • Alcoholic Extract
  • Spontaneous Motor Activity