Summary
Acidic polysaccharides (AP) are released from Propionibacterium acnes I and II during growth. Similar antigens are released from two strains of P. avidum, but in a smaller amount. Furthermore, prostaglandin-like substances (PLS) have been isolated from the lipid fraction of P. acnes.
The AP antigens give rise to a precipitation reaction against a large proportion of normal sera. However, significantly higher antibody titre levels towards the AP fraction were found in patients with severe acne vulgaris. No rise of antibodies was found towards PLS. These findings suggest that AP's may contribute to the inflammatory response in acne vulgaris as antigens, whereas PLS, as one of the potential mediators trigger development of the initial lesions.
Zusammenfassung
Saure Polysaccharide (AP) werden von dem Propionibacterium acnes I und II während des Wachstums freigesetzt. Ähnliche Antigene werden von zwei Stämmen des P. avidum liberiert, jedoch in einem geringeren Ausmaß. Weiterhin wurden Prostaglandin-ähnliche Substanzen (PLS) von der Lipidfraktion von P. acnes isoliert. Die AP-Antigene führen zu einer präzipitierenden Reaktion gegen Normalserum. Es wurden jedoch signifikant höhere Antikörpertiter gegen diese AP-Fraktion bei Patienten mit schwerer Akne vulgaris gefunden. Eine Erhöhung von Antikörpern gegen PLS wurde nicht festgestellt. Diese Resultate lassen die Annahme zu, daß saure Polysaccharide an dem Zustandekommen der entzündlichen Reaktion bei der Akne vulgaris in Form von Antigenen beteiligt sind, während prostaglandin-ähnliche Substanzen als eine der potentiellen Mediatoren, die Entwicklung einer Frühreaktion stimulieren.
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Dalen, A., Hellgren, L., Iversen, O.J. et al. Antibodies against extractable components from Propionibacterium acnes in humans with and without acne vulgaris. Arch Dermatol Res 269, 253–259 (1980). https://doi.org/10.1007/BF00406418
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DOI: https://doi.org/10.1007/BF00406418