Summary
A 30,000–50,000 molecular weight (MW) extract of thymus and spleen from 11 age groups of untreated AKR mice, 1–210 days old, was tested for in vitro effect on thymide incorporation into normal AKR lymph node cells, normal spleen cells, and leukemic thymocytes. Extracts from mice up to 5 months of age mostly had slightly inhibitory effect but concomitant with emergence of thymus leukemia in the 6-month-old mice, the extract acquired a strongly mitogenic effect on normal lymph node cells. Seven-month-old, non-leukemic animals again yielded extracts with inhibitory effect.
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References
Ebbesen P, Olsson L, Rudkøbing O, Haahr S, Kristensen G (1977) Correlation of in vivo cancer, net outer charge, in vitro migration interferon activity, in vitro growth rates, and chalone-like activity to transformation-reversion in cloned Moloney and Kirsten sarcoma virus transformed mouse 3T3 cells. Cancer Res 37:4285–4290
Ebbesen P, Olsson L (1978) Specificity of the inhibition of DNA synthesis by extracts from cloned normal sarcoma virus-transformed and revertant 3T3 cells. Br J Cancer Res 38:732–736
McGrath and Weissman (1978)
Staats J (1972) Standardized nomenclature for inbred strains of Mio Fifth Lishing. Cancer Res 32:1609–1637
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Supported by the US Health Education and Welfare grant no. IROI CA 26109-01, Commission of the European Communities contract no. 251-77-1 BIO DK, and The Carlsberg Foundation
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Ebbesen, P., Olsson, L. Stimulatory effect on DNA synthesis of thymus and spleen extract from leukemic AKR mice. J Cancer Res Clin Oncol 100, 105–107 (1981). https://doi.org/10.1007/BF00405907
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DOI: https://doi.org/10.1007/BF00405907