Summary
Leukocyte alkaline phosphatase (LAP) activity in peripheral blood was determined in 113 patients with non-metastatic malignancies, 36 patients with metastatic spread, and 22 individuals who served as controls. The LAP score of the non-metastatic cancer patients was significantly higher (p<0.001) than the controls, and the score of the metastatic group was further increased significantly as compared to both control (p<0.001) and nonmetastatic groups (p<0.001).
The results of this survey suggest that the level of LAP score in peripheral blood might be used to differentiate between non-metastatic and metastatic disease and might serve as an aid in prognosis of the patients.
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Walach, N., Kaufman, S. & Horn, Y. Leukocyte alkaline phosphatase in cancer patients. J Cancer Res Clin Oncol 100, 69–72 (1981). https://doi.org/10.1007/BF00405903
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DOI: https://doi.org/10.1007/BF00405903