Summary
The intra-articular injection of ascites fluid or of extracts derived from malignant tumors was shown to induce exudative joint lesions. The intraarticular injection of normal plasma did not have this effect. It is suggested that tumor secretes a permeability-enhancing agent. This substance promotes the extravasation of humoral or cellular elements into the joint spaces. A similar mechanism may underlie the development of pulmonary arthropathy or the formation of malignant effusions.
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Stein-Werblowsky, R. A permeability-enhancing factor produced by tumor. J Cancer Res Clin Oncol 97, 315–320 (1980). https://doi.org/10.1007/BF00405784
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DOI: https://doi.org/10.1007/BF00405784