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Implantation of cigarette somoke condensate in the lungs of Syrian golden hamsters

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Summary

Different doses of benzo(a)pyrene, cigarette smoke condensate (CSC) and its nitromethane fraction (NMF), in wax pellets, were directly implanted into the lungs of Syrian golden hamsters. Pleomorphic sarcomas were induced in the B(a)P treated animals. Several epithelial proliferative lesions and a few bronchiogenic adenomas were induced in CSC and NMF treated hamsters. A species-specific effect has been observed in this investigation.

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References

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Authors and Affiliations

  1. Abteilung für experimentelle Pathologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany

    M. B. Ketkar, H. Haas & J. Althoff

Authors
  1. M. B. Ketkar
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  2. H. Haas
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  3. J. Althoff
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Additional information

The authors are grateful to BAT Cigarettenfabriken GmbH, Hamburg, FRG, for partial support of these investigations

The authors would like to thank Prof. Dr. U. Mohr for his critical advice and assistance with this paper and Jenny Ross for her help with the manuscript

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Ketkar, M.B., Haas, H. & Althoff, J. Implantation of cigarette somoke condensate in the lungs of Syrian golden hamsters. J Cancer Res Clin Oncol 94, 111–114 (1979). https://doi.org/10.1007/BF00405354

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  • DOI: https://doi.org/10.1007/BF00405354

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