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Use of radioactive gold in the treatment of pleural effusions caused by metastatic cancer

Radio-Gold-Applikation zur behandlung von Pleura-Ergüssen verursacht durch krebsmetastasen

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  • Clinical Oncology or Epidemiology
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Zusammenfassung

12 Patientinnen mit disseminierender karcinomatöser Erkrankung des gynäkologischen Fachbereichs und gleichzeitiger Pleuritis carcinomatosa wurden wenigstens einmal mit einer intrapleuralen Radio-Gold-Applikation behandelt, nachdem die Pleurapunktionsfrequenz die Zeit von drei Wochen unterschritt. Von diesen 12 Patientinnen zeigten 3 ein vollständiges Verschwinden des Pleura-Ergusses nach 4 wöchiger Kontrolluntersuchung, bei 5 Patientinnen trat eine deutliche Besserung ein, 4 Patientinnen zeigten keinen Therapieerfolg. Schwere Komplikationen waren minimal und mit Studien einfacher Thorakozentesen vergleichbar.

Summary

This paper presents a series of 12 patients suffering from advanced gynecological cancer with the occurrence of pleural effusions. All patients received at least one intrapleural dose of radioactive gold (100 m Ci Au198) when the necessity for thoracentesis became more than once every three weeks. Three showed no recurrence of fluid, five a significant slowing down of effusion, and four did not show any response. Severe complications were minimal, and were comparable to these resulting from thoracentesis in general.

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Authors and Affiliations

  1. Abt. Geburtshilfe und Gynäkologie, Frauenklinik der Westfälischen Wilhelms-Universität Münster, Westring 11, D-4400, Münster, Federal Republic of Germany

    K. H. Möhlen & F. K. Beller

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  1. K. H. Möhlen
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  2. F. K. Beller
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Möhlen, K.H., Beller, F.K. Use of radioactive gold in the treatment of pleural effusions caused by metastatic cancer. J Cancer Res Clin Oncol 94, 81–85 (1979). https://doi.org/10.1007/BF00405352

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  • DOI: https://doi.org/10.1007/BF00405352

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