Summary
The antitumor agent chloroethyl-cyclohexyl-nitrosourea (CCNU) was examined using a rat glioma model. A i.p. administration of three times 40 mg/kg CCNU was highly effective and increased the life-span of tumor-bearing rats from 53 to 86%. A total quantity of CCNU amounting to less than 30 mg/kg was not effective. On the other hand, large dosages exceeding LD10 proved to be toxic.
The depression of platelets and white blood cells was mild after a single dosage of 40 mg/kg CCNU which recovered on about the 6th day.
In the CCNU-treated animals there was an increase of the extent of necrobiosis. Ballooning of tumor cells with nuclear pyknoses and a lack of mitotic features occurred. Microcystic changes appeared sometimes to be more frequent than in control groups.
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Tamura, M., Mennel, H.D. & Zülch, K.J. Brain tumor chemotherapy using a rat glioma model. J Cancer Res Clin Oncol 94, 39–46 (1979). https://doi.org/10.1007/BF00405348
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DOI: https://doi.org/10.1007/BF00405348