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Comparative studies of neoplastic response to a single dose of nitroso compounds

6.The effect of diethylnitrosamine in syrian golden hamsters

Vergleichende studien hinsichtlich der carcinogenen wirkung nach einmaliger applikation von nitrosoverbindungen

6. Die Wirkung von Diäthylnitrosamin bei Syrischen Goldhamstern

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  • Experimental Oncology
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Zusammenfassung

Die Wirkung einer Einzeldosis von Diäthylnitrosamin (DEN) wurde bei Syrischen Goldhamstern untersucht. Die Tiere wurden bis zum Spontantod beobachtet. Die Minimaldosis, die noch papilläre Polypen in Larynx und Trachea hervorrief, wurde mit 1,03 mg DEN/kg Körpergewicht ermittelt. Induzierte Tumoren in den restlichen Abschnitten des Respirationstraktes oder in anderen Organen wurden nicht gefunden.

Summary

The effect of a single subcutaneous injection of different DEN doses was examined in adult Syrian hamsters observed for life. The minimal effective dose (threshold dose) for neoplastic response, reflected by induction of papillary polyps in the larynx and/or trachea, was 1.03 mg DEN/kg body weight. No tumors were found which could be related to treatment in other segments of the respiratory epithelium nor in other tissues.

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Authors and Affiliations

  1. Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 42nd and Dewey Avenue, 68105, Omaha, NB, USA

    Y. Ii, P. Pour & J. Althoff

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  1. Y. Ii
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  2. P. Pour
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  3. J. Althoff
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Ii, Y., Pour, P. & Althoff, J. Comparative studies of neoplastic response to a single dose of nitroso compounds. J Cancer Res Clin Oncol 94, 1–5 (1979). https://doi.org/10.1007/BF00405344

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  • DOI: https://doi.org/10.1007/BF00405344

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