Summary
The effects of hallucinogens and their nonhallucinogenic analogs on the performance of rats on the Lashley-III underwater maze were evaluated. After the rats were trained to swim through the maze without an error, they were injected i.p. with test compounds or saline solution and tested at various intervals after the injection. A substantial number of the treated animals made one or more errors. The time of peak effect of lysergic acid diethylamide (LSD-25) and mescaline was 15 min after the injection; that of 2-brom-lysergic acid diethylamide (BOL-148) and of several trimethoxyamphetamines (TMA) was 30 min; and that of d-amphetamine was 45 min. The dose-response curves showed that the effect of the compounds was a function of dose. The median effective doses (ED 50) in μmol/kg were: LSD-25 (0.3); TMA-2 (12.8); BOL-148 (15.9); d-amphetamine (32.0); TMA (33.4); TMA-6 (46.0); TMA-3 (52.1); mescaline (91.0); and TMA-4 (94.0). The rank order of potency of the compounds is, in general, similar to that derived from the data on man.
References
Appel, J. B., and D. X. Freedman: The relative potencies of psychotomimetic drugs. Life Sci. 4, 2181–2186 (1965).
Lashley, K. S.: Brain mechanisms and intelligence. A quantitative study of injuries to the brain pp. 31 Chicago: Univ. Chicago Press, 1929.
Litchfield, J. T., Jr., and F. Wilcoxon: A simplified method of evaluating doseeffect experiments. J. Pharmacol. exp. Ther. 96, 99–113 (1949).
Peretz, D. I., J. R. Smythies, and W. C. Gibson: A new hallucinogen, 3,4,5-trimethoxyphenyl-β-aminopropane, with notes on the stroboscopic phenomenon. J. ment. Sci. 101, 317–329 (1955).
Shulgin, A. T.: Psychotomimetic amphetamines methoxy 3,4-dialkoxy-amphetamines. Experientia (Basel) 20, 366–367 (1964).
—, S. Bunnel, and T. Sargent, III: The psychotomimetic properties of 3,4,5-trimethoxyamphetamine. Nature (Lond.) 189, 1011–1012 (1961).
—, T. Sargent, and C. Naranjo: Structure-activity relationships of one-ring psychotomimetics. Nature (Lond.) 221, 537–541 (1969).
Uyeno, E. T.: Inhibition of isolation-induced attack behavior of mice by drugs. J. Pharm. Sci. 55, 215–216 (1966a).
—: Effects of d-lysergic acid diethylamide and 2-brom-lysergic acid diethylamide on dominance behavior of the rat. Int. J. Neuropharmacol. 5, 317–322 (1966b).
—: Hallucinogenic compounds and swimming response. J. Pharmacol. exp. Ther. 159, 216–221 (1968).
—, and W. M. Benson: Effects of lysergic acid diethylamide on attack behavior of male albino mice. Psychopharmacologia (Berl.) 7, 20–26 (1965).
—, L. S. Otis, and C. Mitoma: Behavioral evaluation of hallucinogenic trimethoxyamphetamines in squirrel monkeys. (Saimiri sciureus). Comm. Beh. Biol. 1, 83–90 (1968).
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This work was supported by Contract No. PH-43-65-1061 with the National Institute of General Medical Sciences, the National Institutes of Health, Department of Health, Education and Welfare.
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Uyeno, E.T., Mitoma, C. The relative effectiveness of several hallucinogens in disrupting maze performance by rats. Psychopharmacologia 16, 73–80 (1969). https://doi.org/10.1007/BF00405257
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DOI: https://doi.org/10.1007/BF00405257