Resistance of one-trial discriminated avoidance to chlorpromazine

Summary

Rats were either trained or tested after receiving injections of either 0, 1, 5, or 10 mg/kg of chlorpromazine in an effort to separate drug effects on learning or memory processes from effects on performance. One-trial place avoidance discrimination was used so that response choice could provide a relatively unequivocal indicator of retention. In substantial agreement with previous results, no drug effects on discriminated avoidance were found in spite of profound motor impairment at the highest drug level. Failure of the drug to affect response latencies was discussed in terms of possible contrasting effects on avoidance and motor behavior.