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Brain levels of 3,4-dimethoxyphenylethylamine (DMPEA) and climbing performance of rats

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Abstract

Rat brain levels of 3,4-dimethoxyphenylethylamine (DMPEA) were estimated to be 16 μg/g 20 min after injection of 75 mg DMPEA/kg. The compound is rapidly removed from brain (over 90%) in 2 hours. The amounts in the brain appeared to correlate directly with changes in animal performance of the rope climbing test. The critical level affecting performance of the test was approximately 3 μg/g of brain tissue.

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  1. L. B. Mendel Research Laboratory, Elgin State Hospital, 60120, Elgin, Illinois

    W. H. Vogel & M. K. Horwitt

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  1. W. H. Vogel
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  2. M. K. Horwitt
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Vogel, W.H., Horwitt, M.K. Brain levels of 3,4-dimethoxyphenylethylamine (DMPEA) and climbing performance of rats. Psychopharmacologia 11, 265–269 (1967). https://doi.org/10.1007/BF00405232

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  • DOI: https://doi.org/10.1007/BF00405232

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